Description
BLZ945isaninhibitoroftheCSF-1Rkinasereceptor;itexhibitsimmunostimulatoryandanticancerchemotherapeuticactivitiesandpreventsskeletalmetastasisofdiseases.BLZ945preventsturnoveroftumor-associatedmacrophagesandincreasesCD8+Tcelllevels,limitingtumorgrowthinanimalmodelsofmammarycarcinogenesis.
References
KrauserJA,JinY,WallesM,etal.PhenotypicandmetabolicinvestigationofaCSF-1Rkinasereceptorinhibitor(BLZ945)anditspharmacologicallyactivemetabolite.Xenobiotica.2015Feb;45(2):107-23.PMID:25180976.
StrachanDC,RuffellB,OeiY,etal.CSF1Rinhibitiondelayscervicalandmammarytumorgrowthinmurinemodelsbyattenuatingtheturnoveroftumor-associatedmacrophagesandenhancinginfiltrationbyCD8+Tcells.Oncoimmunology.2013Dec1;2(12):e26968.PMID:24498562.