Description
LevosimendanisacalciumsensitizerthatstABIlizestroponinC,activatesATP-sensitiveK+channels,andinhibitsphosphodiesterases(PDEs).Levosimendanisclinicallyusedtotreatheartfailure,asitimprovescardiacperformanceandmyocardialcontractilitywithoutincreasingoxygenconsumptionordecreasingpreloadorafterload.Levosimendanexhibitsvasodilatoryandcardioprotectiveactivities,improvingleftventricularfunctioninanimalmodelsofmyocardialischemia/reperfusion.
References
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