BiologicalActivity
Antiallergicviainhibitionofchemicalmediatorreleasefrommastcells.Showntobeaneffectiveinhibitorofangiogenesis.DemonstratedtoantagonizetheeffectsofangiotensinIIonhumanarteries,possIBLybyaninteractionattheleveloftheAT1receptor.InhibitsTRPV2-mediatedresponses;bindstoAβ40monomersandincreasesAβ40fibrillation.
CompoundLibraries
TranilastisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 327.34 |
| Formula | C18H17NO5 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 53902-12-8 |
| PubChemID | 5282230 |
| InChIKey | NZHGWWWHIYHZNX-CSKARUKUSA-N |
| Smiles | COC1=CC=C(C=CC(=O)NC2=CC=CC=C2C(O)=O)C=C1OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight327.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.27mL | 30.55mL |
| 5mM | 0.61mL | 3.05mL | 6.11mL |
| 10mM | 0.31mL | 1.53mL | 3.05mL |
| 50mM | 0.06mL | 0.31mL | 0.61mL |
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