BiologicalActivity
SelectiveNa+/Ca2+-exchange(NCX)inhibitor;displayssomeselectivityforNCX1.IC50valuesare2.9,16and8.6μMforinhibitionofintracellularNa+-dependent45Ca2+uptakebycellsexpressingNCX1,NCX2andNCX3respectively.HassomeaffinityformAChreceptors(IC50=18μM)butminimalactivityagainstNCKX2andvariousreceptorsandionchannels(IC50>30μM).PreferentiallyblocksCa2+influxmodeandismoreselectiveforNCXisoformsthanKB-R7943(Cat.No.1244).Anti-ischemic;potentlyprotectsagainsthypoxia-inducedrenaltubularcelldamage(IC50=0.63μM).
CompoundLibraries
SN-6isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 402.16 |
| Formula | C20H22N2O5S |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 415697-08-4 |
| PubChemID | 10222761 |
| InChIKey | ZVYIJXLMBWCGHP-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.22 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight402.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.49mL | 12.43mL | 24.87mL |
| 5mM | 0.5mL | 2.49mL | 4.97mL |
| 10mM | 0.25mL | 1.24mL | 2.49mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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