BiologicalActivity
Potentandselectivenoradrenalinre-uptakeinhibitor(Kivaluesare5,77and1451nMforinhibitionofrADIoligandbindingtohumanNET,SERTandDATrespectively).Displaysminimalaffinityforarangeofotherneurotransmitterreceptorsandtransporters(Ki>1μM).Antidepressant.
TechnicalData
| M.Wt | 291.82 |
| Formula | C17H21NO.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 82248-59-7 |
| PubChemID | 54840 |
| InChIKey | LUCXVPAZUDVVBT-UNTBIKODSA-N |
| Smiles | Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.59 | 50mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight291.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.43mL | 17.13mL | 34.27mL |
| 5mM | 0.69mL | 3.43mL | 6.85mL |
| 10mM | 0.34mL | 1.71mL | 3.43mL |
| 50mM | 0.07mL | 0.34mL | 0.69mL |
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