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Tocris/VU 0463271/4719/50/50 mg
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Description:PotentandselectiveKCC2inhibitor
ChemicalName:N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectiveinhibitoroftheneuronalK-Clcotransporter,KCC2(IC50=61nM);displays>100-foldselectivityversustheNa-K-2Clcotransporter1(NKCC1)andnoactivityagainstapanelof68GPCRs,ionchannelsandtransporters.
TechnicalData
M.Wt | 382.5 |
Formula | C19H18N4OS2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1391737-01-1 |
PubChemID | 70690453 |
InChIKey | DPONSKCACOZTGN-UHFFFAOYSA-N |
Smiles | O=C(N(C4CC4)C3=NC(C)=CS3)CSC(C=C2)=NN=C2C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.12 | 50 | |
ethanol | 3.83 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight382.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.61mL | 13.07mL | 26.14mL |
5mM | 0.52mL | 2.61mL | 5.23mL |
10mM | 0.26mL | 1.31mL | 2.61mL |
50mM | 0.05mL | 0.26mL | 0.52mL |
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ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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