Tocris产品目录价格美国Tocris Bioscience公司,Tocris/BMS 536924/4774/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

商品信息

联系客服

郑重提醒：

无质量问题不接受退换货，下单前请仔细核对信息。

下单后请及时联系客服核对商品价格，订单生效后再付款。

Tocris/BMS 536924/4774/10/10 mg

品牌 /

Tocris Bioscience

货号 /

4774/10

官网地址

美元价：

登录查看

(友情提示：该价格仅为参考，欢迎联系客服询价！)

数量：

免费咨询热线

4000-520-616

商品介绍售后保障相关文章商品咨询

联系客服

Description:DualIR/IGF1Rinhibitor

ChemicalName:4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Dualinhibitoroftheinsulinreceptor(IR)andinsulin-likegrowthfactor-1receptor(IGF1R)(IC₅₀valuesare73and100nMrespectively).InhibitsreceptorautophosphorylationanddownstreamMEK1/2andAktsignaling.InducesG₁arrestandapoptosisinML-1cells;alsoinhibitscellproliferationinmultipletumortypes.ReversesEMTthroughtheattenuationofSnailmRNAexpressioninMCF10AcelloverexpressingIGF1R.

CompoundLibraries

BMS536924isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	479.96
Formula	C₂₅H₂₆ClN₅O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	468740-43-4
PubChemID	6077765
InChIKey	DXEATJQGQHDURZ-DEDYPNTBSA-N
Smiles	O=C1NC=CC(NC[C@H](C5=CC=CC(Cl)=C5)O)=C1C3=NC2=CC(N4CCOCC4)=CC(C)=C2N3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	48	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight479.96.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.08mL	10.42mL	20.84mL
5mM	0.42mL	2.08mL	4.17mL
10mM	0.21mL	1.04mL	2.08mL
50mM	0.04mL	0.21mL	0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage:

BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets