Tocris美元价/进货价 Tocris离子通道调控剂,Tocris/APcK 110/3704/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/APcK 110/3704/50/50 mg

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Tocris Bioscience

货号 /

3704/50

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4000-520-616

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Description:KITinhibitor

ChemicalName:6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

KITinhibitor;inhibitsphosphorylationofKIT,STAT3,STAT5andAkt.SuppressesproliferationofOCI/AML3cells(IC₅₀=175nM).Caspase-dependantapoptosisinducer.

CompoundLibraries

APcK110isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	349.36
Formula	C₂₀H₁₆FN₃O₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1001083-74-4
PubChemID	24786010
InChIKey	CAMGZGMEPKFVMF-UHFFFAOYSA-N
Smiles	FC(C=C3)=CC=C3C1=NNC2=C1C=CC(C4=CC(OC)=CC(OC)=C4)=N2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	34.94	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight349.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.86mL	14.31mL	28.62mL
5mM	0.57mL	2.86mL	5.72mL
10mM	0.29mL	1.43mL	2.86mL
50mM	0.06mL	0.29mL	0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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