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Description

Cytochalasin B is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin B inhibits secretion of corticosterone and aldosterone from the adrenal gland in vivo. In fibroblasts, cytochalasin B inhibits FGF- and PDGF-induced mitogenesis. Additionally, this compound’s disruption of actin polymerization prevents phagocytosis in macrophages.

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References

Delarue C, Esneu M, Fournier A, et al. Role of the cytoskeleton in the secretory response of the frog adrenal gland to calcitonin gene-related peptide. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):21-7. PMID: 9449202.

Reist RH, Dey RD, Durham JP, et al. Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine. Toxicol Appl Pharmacol. 1993 Sep;122(1):70-6. PMID: 8104360.

Painter RG, Whisenand J, McIntosh AT. Effects of cytochalasin B on actin and myosin association with particle binding sites in mouse macrophages: implications with regard to the mechanism of action of the cytochalasins. J Cell Biol. 1981 Nov;91(2 Pt 1):373-84. PMID: 7198123.