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Signalchem/GRK3, Active/10 ug/A15-11G-10
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产品说明
Overview:GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function (1). GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue (2). Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have beenassociated with bipolar disorder. Gene Aliases:ADRBK2; BARK2 Genbank Number:NM_005160 References:1. Benovic, J. L. et.al: Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2: a new member of the receptor kinase family. J. Biol. Chem. 266: 14939-14946, 1991.2. Parruti, G. et.al: Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. Biochem. Biophys. Res. Commun. 190: 475-481, 1993.
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