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Signalchem/AMPK (A1/B1/G1), Active/5 ug/P47-10GH-05
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Overview:AMPK is a heterotrimer protein kinase consisting of a α catalytic subunit, and non-catalytic β and γ subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status (1). In response to cellular metabolic stresses, AMPK is activated and phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating biosynthesis of fatty acid and cholesterol (2). Gene Aliases:Subunit A1: PRKAA1, MGC33776, MGC57364Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785Subunit G1: PRKAG1, AMPKG, MGC8666 Genbank Number:NM_006251NM_006253NM_002733 References:1. Minokoshi, Y. et al:AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574, 2004.2. Hardie, D G. et al: The AMP-activated protein kinase--fuel gauge of the mammalian cells Eur J Biochem. 1997 Jun 1;246(2):259-73.

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