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Signalchem/MASTL, Active/5 ug/M72-10G-05
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产品说明
Overview:Microtubule associated serine/threonine kinase-like (MASTL) belongs to the MAST family, AGC Ser/Thr protein kinase group. MASTL promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation, separation, and other aspects of mitotic progression, which is primarily mediated by inhibiting PP2A/B55δ. Overexpression of MASTL is correlated with cancer progression, poor patient survival, and tumor recurrence in various cancers. Gene Aliases:GREATWALL; GW; GWL; hGWL; RP11-85G18.2; THC2 Genbank Number:NM_001172303 References:1. Wang L, et al. Mastl kinase, a promising therapeutic target, promotes cancer recurrence. Oncotarget. 5:11479-89, 2014.2. Zhao Y, et al. Roles of Greatwall kinase in the regulation of cdc25 phosphatase. Mol Biol Cell. 19:1317-27, 2008.
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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