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Signalchem/PKC alpha, Active/10 ug/P61-18G-10
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产品说明
Overview:PKCα is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC-alpha has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control(1). PKCα has been assigned to the chromosome region 17q22-q23.2 and has been identified as a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes (2). Gene Aliases:AAG6, PKCA, PRKCA, PRKACA, MGC129900, MGC129901 Genbank Number:NM_002737 References:1.Coussens, L. et al: Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 233: 859-866, 1986. 2.Braz, J C. et al: PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Med. 10: 248-254, 2004.
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