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Signalchem/PIM3, Active/5 ug/P37-10BG-05
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Overview:PIM3 or PIM-3 oncogene belongs to a family of protooncogenes that encode serine/threonine protein kinases (1). Pim-3 expressed in hepatocellular carcinoma development and plays a main role in the proliferation of human hepatoma cell lines (2). Pim-3 also expressed in human pancreatic cancer cell and phosphorylates BAD to block Bad-mediated apoptosis in human pancreatic cancer cell lines (3). Gene Aliases:PIM-3 Genbank Number:NM_001001852 References:1. Mikkers, H. et.al: Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Molec. Cell. Biol. 24: 6104-6115, 2004.2. Fujii, C. et.al: Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int. J. Cancer 114: 209-218, 2005.3. Li, Y.-Y. et.al: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res. 66: 6741-6747, 2006.
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