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Signalchem/TRIO, Active/10 ug/T16-11G-10
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产品说明
Overview:TRIO (Triple functional domain protein) belongs to CAMK Ser/Thr protein kinase family with 5 isoforms produced by alternative splicing. It encodes two Dbl-homology-Pleckstrin-homology (DH-PH) Rho-GEF units with different specificities and a C-terminal serine/threonine kinase domain.It is a Rho-guanine nucleotide exchange factors (GEFs) that catalyzes exchange of GDP for GTP on small Rho-GTPases, such as Rac1, RhoG and RhoA.TRIO was originally identified as a binding partner of the transmembrane tyrosine phosphatase LAR, and they together play a role in coordinating cell-matrix and cytoskeletal rearrangements required for cell migration and cell growth. Gene Aliases:(None) Genbank Number:O75962-1 References:1. Debant A, et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A. 93:5466-71. 1996.2. van Rijssel J, et al: The many faces of the guanine-nucleotide exchange factor trio. Cell Adh Migr. 6:482-7. 2012.
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