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Signalchem/CK1 alpha 1L, Active/10 ug/C75-10G-10
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Overview:CK1alpha1L or casein kinase 1, alpha 1 like is a novel member of the CKI gene family which highlights a critical role for p53 in invasiveness control (1). CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1 and it governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival (2). Gene Aliases:CSNK1A1L, CK1A1L, CK1alpha1L, CK1, MGC33182, RP11-532O21.2 Genbank Number:BC028723 References:1. Elyada, E.et.al: CKI-alpha ablation highlights a critical role for p53 in invasiveness control. Nature 470: 409-413, 2011.2. Bidere, N.et.al: Casein kinase 1-alpha governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. Nature 458: 92-96, 2009.
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