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Signalchem/AMPK (A2/B1/G1), Active/10 ug/P48-10H-10
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Overview:AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes (1). AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization (2). Gene Aliases:Subunits A2: PRKAA2, AMPK, AMPK2, PRKAASubunit B1: PRKAB1, AMPK, HAMPKb, MGC17785Subunit G1: PRKAG1, AMPKG, MGC8666 Genbank Number:NM_006252NM_006253NM_002733 References:1.Viollet, B. et al: Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans. 2003; 31; 216–219.2.Foretz, M. et al: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes, 2005; 54 (5);1331-1339.
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