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StressMarq/17-AAG/SIH-100A/1-mg

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SIH-100A

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Overview:ProductName17-AAGDescriptionHsp90inhibitorPurity>98%(TLC);NMR(Conforms)CASNo.75747-14-7MolecularFormulaC31H43N3O8MolecularWeight585.7PropertiesStorageTemperature-20ºCShippingTemperatureShippedAmbientProductTypeInhibitorSolubilitySolubleinDMSO(>50mg/ml)orethanol(5mg/ml)SourceSyntheticAppearanceRedtodarkredpowderSMILESC[[email protected]]1C[[email protected]@H]([[email protected]@H]([[email protected]](/C=C(/[[email protected]@H]([[email protected]](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)C)C)O)OCInChIInChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30InChIKeyAYUNIORJHRXIBJ-TXHRRWQRSA-NSafetyPhrasesClassification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionCiteThisProduct17-AAG(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-100)BIOLOGicalDescriptionAlternativeNames17-(Allylamino)-17-demethoxygeldanamycin,17-(Allylamino)geldanamycin,17-Demethoxy-17-allylaminogeldanamycin,17-AAG,CP127374,Geldanamycin,17-demethoxy-17-(2-propenylamino)-,NSC330507,TanespimycinResearchAreasCancer,HeatShockPubChemID6505803ScientificBackgroundGlendanamycin(GA),abenzoquinoneansamycinantibiotic,interfereswiththeactionofHsp90leADIngtodegradationofHsp90clientproteins.GAitselfhoweverhasundesirablepropertiessuchaspooraqueoussolubilityandlivertoxicity;therefore,numerousanalogshavebeensynthesized,suchas17-AAG(1).17-AAGisanHSP-90inhibitorthatdisplaysa100-foldhigheraffinityforHSP-90derivedfromtumorcellscomparedtoHSP-90fromnormalcells(2).17-AAGinhibitsAktactivationandexpressionintumorsandsynergizeswithanumberofantitumoragentssuchastaxol(3),cisplatin(4)andUCN-01(400nM17-AAG,U937cells)(5).LookingformoreinformationonHSP90?VisitournewHSP90ScientificResourceGuideathttp://www.HSP90.ca.References1.NeckersL.(2002)TrendsMolMed.84:S55-61.2.KamalA.,etal.(2003)Nature.425:407.3.SolitD.B.,etal.(2003)CancerRes.63:2139.4.VasilevskayaI.A.,etal.(2003)Mol.Pharmacol.65:235.5.JiaW.,etal.(2003)Blood.102:1824.ProductImagesChemicalstructureof17-AAG(SIH-100),aHsp90inhibitor.CAS#:75747-14-7.MolecularFormula:C31H43N3O8.MolecularWeight:585.7g/mol.ProductCitations(0)Currentlytherearenocitationsforthisproduct.

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。