首页 > StressMarq > StressMarq/Anti-Abl1 Antibody (pTyr264)/SPC-904D-P594/100-µl

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StressMarq/Anti-Abl1 Antibody (pTyr264)/SPC-904D-P594/100-µl

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Overview: Product Name Abl1 Antibody (pTyr264) DescriptionRabbit Anti-Human Abl1 (pTyr264) Polyclonal Species Reactivity Human Applications WB, AM Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user. Host Species Rabbit Immunogen Species Human Immunogen A phospho-specific peptide corresponding to residues surrounding Tyr264 of human Abl1- pY469 (AA466-472) Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated Properties Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal Storage Temperature -20ºC Shipping Temperature Blue Ice or 4ºC Purification Peptide Affinity Purified Clonality Polyclonal Specificity Detects 122.945 kDa. Cite This Product StressMarq Biosciences Cat# SPC-904, RRID: AB_2706671 Certificate of Analysis A 1:250 dilution of SPC-904 was sufficient for detection of Abl1 (pTyr264) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Biological Description Alternative Names Abelson tyrosine protein kinase 1 Antibody, ABL Antibody, c ABL Antibody, p150 Antibody, bcr/abl Antibody Research Areas Cancer, Cell Signaling, Epigenetics and Nuclear Signaling, Oncoproteins, Protein Phosphorylation, Transcription, Tumor Biomarkers, Tyrosine Kinases Cellular Localization Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus Accession Number NP_005148 Gene ID 25 Swiss Prot P00519 Scientific Background ABL1 is a widely-expressed, non-receptor protein-tyrosine kinase. It is stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. It is activated by autophosphorylation as well as by Src-family kinase-mediated phosphorylation. It can also be activated by RIN1 binding to the SH2 and SH3 domains. As it is stimulated by cell death inducers and DNA-damage, it is likely that the wild-type form of Abl1 is actually a tumour -suppressor protein. The normal active form of Abl1 is nuclear, and it is sequestered into the cytoplasm by interaction with 14-3-3 through Thr-735. It localizes to the mitochondria under conditions of oxidative stress. Product Images Currently there are no images for this product Product Citations (0) Currently there are no citations for this product. PE/ATTO 594PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm.Overview:High fluorescence yieldHigh photostabilityVery hydrophilicExcellent solubility in waterVery little aggregationPE/ATTO 594 DatasheetOptical Properties:λex = 535 nmλem = 627 nmLaser = 488 to 561 nm

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。