首页 > StressMarq > StressMarq/Anti-BRK Antibody (pSer446 + pTyr447)/SPC-926D-RPE/100-µl

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StressMarq/Anti-BRK Antibody (pSer446 + pTyr447)/SPC-926D-RPE/100-µl

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SPC-926D-RPE

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Overview: Product Name BRK Antibody (pSer446 + pTyr447) DescriptionRabbit Anti-Human BRK (pSer446 + pTyr447) Polyclonal Species Reactivity Human Applications WB, AM Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user. Host Species Rabbit Immunogen Species Human Immunogen A phospho-specific peptide corresponding to residues surrounding Ser446 and Tyr447 of human BRK (AA443-450) Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated Properties Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal Storage Temperature -20ºC Shipping Temperature Blue Ice or 4ºC Purification Peptide Affinity Purified Clonality Polyclonal Specificity Detects 51.834 kDa. Cite This Product StressMarq Biosciences Cat# SPC-926, RRID: AB_2707067 Certificate of Analysis A 1:250 dilution of SPC-926 was sufficient for detection of BRK (pSer446 + pTyr447) in 10 µg of human A549 cell line lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Biological Description Alternative Names Breast tumor kinase Antibody, Protein tyrosine kinase 6 Antibody, Ptk6 Antibody, PTK6_HUMAN Antibody, Tyrosine protein kinase BRK Antibody Research Areas Cancer, Cell Signaling, Protein Phosphorylation, Tyrosine Kinases Cellular Localization Cytoplasm, Nucleus Accession Number NP_005966 Gene ID 5753 Swiss Prot Q13882 Scientific Background BRK otherwise known as PTK6, is a protein-tyrosine kinase. It is a cytoplasmic nonreceptor protein-kinase that seems to function as an intracellular signal transducer in epithelial tissues. Upregulation of this gene in mammary epithelium causes sensitization to epidermal growth factor (EGF) and results in a partially transformed phenotype. Upregulation of this gene has been found in some breast cancers, while mutation in this gene have been found in skin, ovairan, and gastric tumours. Product Images Currently there are no images for this product Product Citations (0) Currently there are no citations for this product. R-PE (R-Phycoerythrin)Overview:Broad excitation spectrumHigh quantum yieldPhotostableMember of the phycobiliprotein familyIsolated from red algaeExcellent solubility in waterMolecular Weight: 250 kDaR-PE Datasheet Optical Properties:λex = 565 nmλem = 575 nmεmax = 2.0×106 Φf = 0.84Brightness = 1.68 x 103Laser = 488 to 561 nmFilter set = TRITC

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。