首页 > StressMarq > StressMarq/Anti-FGFR2 Antibody (pTyr656 + pTyr657)/SPC-983D-A594/100-µl

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StressMarq/Anti-FGFR2 Antibody (pTyr656 + pTyr657)/SPC-983D-A594/100-µl

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SPC-983D-A594

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Overview: Product Name FGFR2 Antibody (pTyr656 + pTyr657) DescriptionRabbit Anti-Human FGFR2 (pTyr656 + pTyr657) Polyclonal Species Reactivity Human Applications WB, AM Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user. Host Species Rabbit Immunogen Species Human Immunogen A phospho-specific peptide corresponding to residues surrounding Tyr647 and Tyr648 of human FGFR3 (AA644-651) Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated Properties Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal Storage Temperature -20ºC Shipping Temperature Blue Ice or 4ºC Purification Peptide Affinity Purified Clonality Polyclonal Specificity Detects 87.710 (110-120) kDa. Cite This Product StressMarq Biosciences Cat# SPC-983, RRID: AB_2708093 Certificate of Analysis A 1:250 dilution of SPC-983 was sufficient for detection of FGFR2 (pTyr656 + pTyr657) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Biological Description Alternative Names ACH Antibody, CD333 Antibody, FGFR3 Antibody, CEK2 Antibody, Fibroblast growth factor receptor 3 Antibody, Heparin binding growth factor receptor Antibody, HSFGFR3EX Antibody, Hydroxyaryl protein kinase Antibody, JTK4 Antibody, MFR 3 Antibody, SAM 3 Antibody, Tyrosine kinase JTK 4 Antibody, Tyrosine kinase JTK4 Antibody, Z FGFR 3 Antibody Cellular Localization Cell membrane, Cytoplasmic Vesicle, Endoplasmic Reticulum Accession Number NP_000133 Gene ID 2261 Swiss Prot P22607 Scientific Background FGFR3 is a receptor-tyrosine kinase that is activated upon binding fibroblast growth factor (FGF). Extracellular ligand binding induces homo- or hetero- dimerization of FGFR to activate signalling. FGFRs have an essential role in regulating cellular differentiation, proliferation and apoptosis. The FGFR3 isoform is specifically involved in chondrocyte development which is physiologically linked to normal skeleton development. Defects in FGFR3 can lead to dwarfism. Overexpressed FGFR3 can promote activation of SHP2 and STAT signalling pathways.Mutations which promote constitutive dimerization of FGFR and kinase activation or impairs internalization and degradation of the receptor have been observed in bladder, skin and oral cancers. Product Images Currently there are no images for this product Product Citations (0) Currently there are no citations for this product. ATTO 594Overview:High fluorescence yieldHigh photostabilityVery hydrophilicExcellent solubility in waterVery little aggregationNew dye with net charge of -1Molar Mass: 1137 g/molATTO 594 Datasheet Optical Properties:λex = 601 nmλem = 627 nmεmax = 1.2×105Φf = 0.85τfl = 3.5 nsBrightness = 102Laser = 594 nmFilter set = Texas Red®

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。