首页 > StressMarq > StressMarq/HSP65 Protein/SPR-116B/100-µg

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StressMarq/HSP65 Protein/SPR-116B/100-µg

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SPR-116B

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Overview:ProductNameHSP65ProteinDescriptionMycobacteriumbovisBCGRecombinantHSP65PartialProteinApplicationsWB,SDS-PAGE,FunctionalAssay,ELISAConcentrationLot/batchspecific.Seeincludeddatasheet.ConjugatesNotagPropertiesStorageBuffer20mMTris,150mMNaCl,10%glycerolStorageTemperature-20ºCShippingTemperatureBlueIceor4ºCPurificationMulti-StepPurifiedSpecificity~65kDaCiteThisProductMycobacteriumbovisBCGRecombinantHSP65Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-116)CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDS-PAGEanalysis.BIOLOGicalDescriptionAlternativeNames60kDachaperonin2Protein,AntigenAProtein,CellwallproteinAProtein,groELProtein,GroEL2Protein,GroL2Protein,M.TuberculosiscellwallproteinAProtein,M.TuberculosisHSP65Protein,ProteinCpm602ProteinResearchAreasCancer,HeatShockCellularLocalizationCytoplasmAccessionNumberAAQ64501.1SwissProtQ1EHB9ScientificBackgroundHSP65isolatedfromMycobacteriumbovisBCG,isamemberoftheHSP60familyofheatshockproteins(2,3).HSP60saremitochondrialchaperoninsthataretypicallyheldresponsIBLeforthetransportationandrefoldingofproteinsfromthecytoplasmintothemitochondrialmatrix.Inadditiontoitsroleasaheatshockprotein,HSP60functionsasachaperonintoassistinfoldinglinearaminoacidchainsintotheirrespectivethree-dimensionalstructure.HSP60sareaubiquitousclassofHSPsthatspecificallypromotethefoldingandassemblyofcellularpolypeptidesinanATP-dependentmanner(1).Specifically,sequencecomparisonofHSP65fromdifferentmycobacteriumstrainsshowedthattheproteinsequenceofM.bovisBCGisidenticaltothatofM.tuberculosis,andverysimilartothatofM.leprae,thepathogensthatcausetuberculosisandtuberculoidleprosy,respectively(2,4).MycobacteriumbovisBCGHSP65wasidentifiedastheimmunodominantantigenduringmycobacterialdiseasesandvaccination.Itisalsobelievedtobetheantigenthatinducesautoimmunedisease,suchasadjuvantarthritisinrats(5,6).References1.KollH.,etal.(1992)Cell.68:1163-1175.2.TholeJ.E.R.,etal.(1985)Infect.Immuno.50:800-806.3.TholeJ.E.R.,etal.,(1987)Infect.Immuno.55:1466-1475.4.ShinnickT.M.SweetserD.,TholeJ.,vanEmBDenJ.andYoungR.A.(1987)Infect.Immuno.55:1932-1935.5.VanEdenW.,etal.(1988)Nature331:171-178.6.CobelensP.M.,etal.(2002)Rheumatology41:775-779.ProductImagesSDS-PAGEof65kDaM.BovisHsp65protein(SPR-116).ProductCitations(6)ELISAPutativeconsequencesofexposuretoHelicobacterpyloriinfectioninpatientswithcoronaryheartdiseaseintermsofhumoralimmuneresponseandinflammation.Matusiak,A.etal.(2016)ArchMedSci.12(1):45–54.PubMedID:26925118Applications:ELISAOtherCitationsIdentificationofmycobacterialRplJ/L10andRpsA/S1proteinsasnoveltargetsforCD4+Tcells.Johnson,A.J.etal.(2017)InfectImmun.85(4).pii:e01023-16.PubMedID:28115505Applications:ProteinBindingAssayLckInhibitsHeatShockProtein65-MediatedReverseCholesterolTransportinTCells.Luo,T.etal.(2016)JImmunol.197(10):3861-3870.PubMedID:27742830Applications:FunctionalAssayHeatshockproteinexpressionaffectshigh-densitylipoproteinfunctioninatherosclerosis.Tang,Y.,Luo,Y.andWu,Q.(2016)IntJClinExpPathol.9(4):4158-4166PubMedID:17920518Applications:FunctionalAssayHeatshockprotein65promotesatherosclerosisthroughimpairingthepropertiesofhighdensitylipoprotein.Sun,H.etal.(2014)Atherosclerosis.237(2):853-61PubMedID:25463133Applications:FunctionalAssayDetectionofautoantibodiesagainstheatshockproteinsandcollapsinresponsemediatorproteinsinautoimmuneretinopathy.Adamus,G.et.al.(2013)BMCOphthalmol.0.575PubMedID:24066722Applications:WesternBlotControl

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。