首页 > StressMarq > StressMarq/Anti-IKKa Antibody (pThr179+pSer180)/SPC-998D-ALP/100-µl

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StressMarq/Anti-IKKa Antibody (pThr179+pSer180)/SPC-998D-ALP/100-µl

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SPC-998D-ALP

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Overview:ProductNameIKKaAntibody(pThr179+pSer180)DescriptionRabbitAnti-HumanIKKa(pThr179+pSer180)PolyclonalSpeciesReactivityHumanApplicationsWB,AMAntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.HostSpeciesRabbitImmunogenSpeciesHumanImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingThr179andSer180ofhumanIKKa(AA177-184)ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,UnconjugatedPropertiesStorageBufferPBSpH7.4,50%glycerol,0.025%ThimerosalStorageTemperature-20ºCShippingTemperatureBlueIceor4ºCPurificationPeptideAffinityPurifiedClonalityPolyclonalSpecificityDetects84.654kDa.CiteThisProductStressMarqBiosciencesCat#SPC-998,RRID:AB_2708363CertificateofAnalysisA1:250dilutionofSPC-998wassufficientfordetectionofIKKa(pThr179+pSer180)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.BIOLOGicalDescriptionAlternativeNamesChukAntibody,CHUK1Antibody,ConservedHelixLoopHelixUbiquitousKinaseAntibody,IKappaBKinase1Antibody,IkBkinasealphasubunitAntibody,IkBKAAntibody,IKK1Antibody,IKKAAntibody,IKKAAntibody,InhibitorOfKappaLightPolypeptideGeneEnhancerInBCellsAntibody,NFKBIKAAntibody,NuclearFactorKappaBInhibitorKinaseAlphaAntibody,NuclearFactorOfKappaLightChainGeneEnhancerInBCellsInhibitorAntibody,TCF16Antibody,Transcriptionfactor16AntibodyCellularLocalizationCytoplasm,NucleusAccessionNumberNP_001269GeneID1147SwissProtO15111ScientificBackgroundIKKaisaprotein-serine/threoninekinase.PhosphorylatesinhibitorsofNF-kappa-BthusleADIngtothedissociationoftheinhibitor/NF-kappa-Bcomplexandultimatelythedegradationoftheinhibitor.Mayplayaspecialroleintheimmuneresponse.LossoffunctionthereforebluntstheNF-kBresponse.CellswithDNAdamageareunabletoundergoapoptosis.Oncogenesismaythereforeoccurindirectlybyinhibittingadownstreamtumoursuppresor(inhibitorsofNF-kB).ProductImagesCurrentlytherearenoimagesforthisproductProductCitations(0)Currentlytherearenocitationsforthisproduct.AP(AlkalinePhosphatase)Properties:Broadenzymaticactivityforphosphateestersofalcohols,amines,pyrophosphate,andphenolsCommonlyusedtodephosphorylatethe5’-terminiofDNAandRNAtopreventself-ligationCatalyzestheconversionof:Chromogenicsubstrates(e.g.pNPP,naphtholAS-TRphosphate,BCIP)intocolouredproductsFluorogenicsubstrates(e.g.4-methylumbelliferylphosphate)intofluorescentproductsMolecularweight:140kDaApplications:Westernblot,immunohistochemistry,andELISAAPDatasheet

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。