首页 > bioporto > bioporto/Anti-Complement component C1s, (human, pro- and activated enzyme)/1kit/ABS 002-49

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bioporto/Anti-Complement component C1s, (human, pro- and activated enzyme)/1kit/ABS 002-49

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ABS002-49

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Cat. No.ABS 002-49SpecificityABS 002-49 is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor.ImmunogenHuman plasma C1s ProenzymeHostMousePositive Species ReactivityHumanNegative Species ReactivityNot determinedIsotypeIgG1/kGene ID716Clone Number49Epitope SpecificityEpitope differs from that of ABS 002-09.Unit Size200 µL: Cat. No. ABS 002-09-021 mL: Cat. No. ABS 002-09-11 mg/mL +/- 15%. See Certificate of Analysis for details.PurificationProtein-A/G purified, from culture supernatantFormLiquidSolvent0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azideConjugationUnconjugated BSA freeStorage4-8ºC without exposure to light. No precautions necessary during handling.TargetC1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.

丹麦Bioporto公司成立于2000年，致力于开发抗体产品及诊断试剂盒。2005年首次开发出NGAL ELISA 试剂盒，该产品于2006年获得欧盟CE认证，可用于急性肾功能损伤的临床诊断和监测。其目标是开发出更多的临床诊断专利产品。