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IQ Products/Complete standardized high quality kit for the diagnosis of HIT/IQP-396

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InformationIntroductionHeparin-inducedthrombocytopenia(HIT)isanacute,immune-mediatedprocessthatmayresultinlife-threateningthrombosis.HITiscausedbyplatelet-activating,heparin-dependentantibodies,whoformcomplexesofheparintogetherwitheitherplateletfactor-4(PF-4)(mostoftheclinicalcases),interleukin-8(IL-8)orneutrophil-activatingpeptide2(NAP-2).Detectionoftheseantibodiesisanimportantlaboratoryfunction.Theantibodiesareinitiallyformedafter5ormoredayswhenapatienthasbeenonheparintherapy.Animmuneresponsetoaheparindosemaybeobservedwithinminutesorhoursifthepatienthashadpreviousexposuretoheparinandantibodiesarealreadycirculating.ThediagnosisofHITisdifficultbecauseitssignsarenon-specificandduetotheabovementionedstructureitisveryimportanttolookforthepresenceandfunctionofthecomplexspecificantibodies.DiagnosticsFordetectionofHITtwodifferentkindofassayscanbeused,theimmunologicalandfunctionalassay.Thefunctionalassaysreproducethein-vivopathophysiology,andhighlycorrelatewiththeclinicalpresentationofHIT.Thisisincontrasttotheimmune-detectionantigen(antigenemia)assays,whichmeasureantibodiesreactivetotheheparinplatelet-factor4(PF4)complexes.However,onlyafractionofpatientspositiveinthesetestsdevelopclinicalHIT.Ontheotherhand,pathogenicantibodiesmayalsoreactwithotherheparincomplexes,suchasheparin-interleukin-8,orheparin-neutrophilactivatingpeptide2,thus,notbeingdetectedbythoseassays.AnimmunologicalassaycanbetheEnzyme-LinkedImmunosorbentAssay(ELISA)ortheGelTest(PaGIA),whichissimilartoELISA.Thedisadvantageofthesetestsisthefactthattheyarenon-functionalassays,theygivemorethan10%falsenegativeanda20%disagreementwithSRA.AfunctionalassayistheSEROtonin-releaseassay(SRA),whichissensitiveandspecific, butnon-feasIBLebecauseoftheuseofrADIoisotypes.AnotherfunctionalassayistheAggregationAssaybutithasalowsensitivityandalongtimetoperform.PrincipleoftheHITAlert™KitRecently,theAmericanCollegeofChestPhysicians(ACCP)haspostedupdatesonrecommendationsfortestingofHIT.ThisshouldfurtherincreasetheneedofhighperformancetestingforHIT.TheHITAlert™Kitissuchatest.FortheHITAlert™Kitdonorplatelets(PRP)areused,whichareincubatedinthepresenceofpatientserumandinthepresenceorabsenceofheparin.WhenpathogenicantibodiesarepresenttheactivationofthedonorplateletsisshownusingaplateletactivationMarker.Byincubatingthesampleswithanantibodyagainstplateletsandtheactivationmarkerthisreactioncanbevisualizedusingflowcytometry.ResultsABCFigure:ResultsofHITAlert™Kit:(A)dotplotofPEpositiveplatelets,(B)negativepatient,(C)positivepatient.

IQ Products公司成立于荷兰，有多种特色产品，如CMV pp65抗原血症分析试剂盒，是一种诊断和监测器官和骨髓移植病人感染活性CMV的全球金标准试剂，也可以诊断和检测AIDS或肿瘤患者中的CMV感染。新喋呤检测试剂盒, 肝素诱导性血小板减少症诊断试剂盒（HIT Alert kit）等临床诊断新产品。

背景介绍

巨细胞病毒(CMV)感染是器官移植术后一种常见的并发症，也是术后早期最主要的感染和死亡原因。据报道，CMV活动性感染率在肾移植受者中为50-75%，其中有10-30%的患者发展为有症状的CMV活动性感染。人外周血CMV pp65的检测可以帮助诊断急性或复发性CMV感染，荷兰IQ 公司研发的CMV Brite Turbo Kit能在EDTA或肝素化的抗凝人外周血中，以免疫荧光的方法快速检测CMV pp65,在器官移植病人中得到了广泛的应用。