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Nordicmubio/Armenian Hamster anti CD27/MUB0366S

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MUB0366S

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Background:CD27(ClusterofDifferentiation247)isatumornecrosisfactorreceptor.Atumornecrosisfactorreceptor(TNFR),ordeathreceptor,isatrimericcytokinereceptorthatbindstumornecrosisfactors(TNF)..TheproteinencodedbythisgeneisamemberoftheTNF-receptorsuperfamily.ThisreceptorisrequiredforgeneRationandlong-termmaintenanceofTcellimmunity.ItbindstoligandCD70,andplaysakeyroleinregulatingB-cellactivationandimmunoglobulinsynthesis.Theimmunesystemhasseveraleffectormechanismsatitsdisposaltofreethehostofpathogens.Becausetheseeffectormechanismscanalsodamagethehost,immuneresponsesshouldbetightlycontrolled.TNFRfamilymembersandtheirrespectiveTNFrelatedligandshavebeenimpliCatedintheregulationofsurvival,prolifeRation,differentiation,andmigRationduringadaptiveimmuneresponses.CD27isalymphoidcell-specificmemberoftheTNFRfamily.HumanandmurineT,B,andNKcellscanexpressCD27InHumans,CD27expressiondistinguishesbetweennaiveandeffector/memorystagesofperipheralBandTlymphocytes.OnBcells,CD27isonlyfoundafterBcellreceptor-inducedactivation.CD27-expressingBcellsfoundinHumanperipheralbloodallhaveundergonesomatichypermutationandthereforeCD27isconsideredaMarkerformemoryBcellsinHumans.RestingTcellsconstitutivelyexpressCD27,whiledifferentiationintoeffectorTcellsisaccompaniedbylossofCD27expression.Source:mAbstomurineCD27weregeneRatedinjectingamixtureofthemCD27tagexpresssingclonesAR0524andAR0530;HamsterspleencellsandSP2/0murinemyelomacellswerefused.Product:Eachvialcontains1mlofculturesupernatantofmonoclonalantibodycontaining0.09%sodiumazide.Applications:LG.8A6isusefulforflowcytometryand,immunoprecipitation.Optimalantibodydilutionshouldbedeterminedbytitration.IncombinationwithLG.3A10,itispossIBLetodevelopadoubledeterminantELISAtodetectsolubleMouseCD27.Specificity:LG.3A10andLG.8A6seeadifferentepitope.AcombinationcanthereforebedevelopedintoadoubledeterminantELISAtodetectsolubleMouseCD27.LG.3A10cross-reactwithHumanCD27,LG.8A6doesnot.Storage:Storeat4°C,orinsmallaliquotsat-20°C.References:1.Gravestein,L.A.,Nieland,J.D.,Kruisbeek,A.M.andBorst,J.Int.Immunol.7:551-557,1995.2.Gravestein,L.,vanEwijk,W.,Ossendorp,F.andBorst,J.J.Exp.Med.184:675-685,1996.3.Hendriks,J.,Gravestein,L.A.,Tesselaar,K.,vanLier,R.A.W.,Schumacher,T.N.M.,andBorst,J.NatureImmunol.1:433-440,2000.Caution:ThisproductisintendedFORRESEARCHUSEONLY,andFORTESTSINVITRO,notforuseindiagnosticortherapeuticproceduresinvolvinghumansoranimals.Thisproductcontainssodiumazide.Topreventformationoftoxicvapors,donotmixwithstrongacidicsolutions.Topreventformationofpotentiallyexplosivemetallicazidesinmetalplumbing,alwayswashintodrainwithcopiousquantitiesofwater.Thisdatasheetisasaccurateasreasonablyachievable,butNordic-MubioacceptsnoliABIlityforanyinaccuraciesoromissionsinthisinformation.

Noridic-Mubio是荷兰的一家著名的免疫学试剂生产厂商，因收购An Der Grub Bio Research GmbH(ADG)，增加了自己的产品线：全球最好的固定破膜剂FIX&PERM 。Nordic-Mubio严格遵照ISO9001标准生产高质量的抗体，主要为针对细胞粘附蛋白、核蛋白和骨架蛋白的抗体。同时Nordic-Mubio也是斑马鱼抗体开发的引领者之一，拥有50多种可用于斑马鱼免疫荧光检测的抗体。