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Nordicmubio/Rabbit anti Drosophila Sphingomyelin synthase-related protein 1/X1861P

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Rabbit anti Drosophila Sphingomyelin synthase-related protein 1Catalogue number: X1861PIsotypeIgG Product Type Polyclonal AntibodyUnits100 µg HostRabbit Species reactivity DrosophilaApplication Western Blotting BackgroundSphingomyelin synthases are enzymes that mediate the biosynthesis of sphingolipid headgroups. Sphingomyelin synthase 1 and 2 (SMS1 and SMS2) mediate the biosynthesis of sphingomyelin, a central sphingolipid in mammalian cells.In addition to SMS1 and SMS2, a third SMS-related protein, SMSr, is known, however its function remains largely unknown.SMSr also occurs in organisms which lack sphingomyelin, such as the fruit fly Drosophila melanogaster.Its function appears to be biosynthesis of ethanolamine phosphorylceramide (EPC), a sphingolipid structurally related to sphingomyelin.SMSr has also been found in mammals as well.Synonyms: SMSr Source Immunogen: Recombinant SMSr derived from Drosophila . Product Product Form: Unconjugated Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Ammonium Sulfate PrecipitationConcentration: See vial for concentration ApplicationsOptimal concentration should be evaluated by serial dilutions.Functional Analysis: Western BlottingPositive Control: Recombinant sphingomelin synthase protein StorageProduct should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles Product Stability: Products are stable for one year from purchase when stored properly Shipping Conditions: Ship at ambient temperature, freeze upon arrival CautionThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information. References1: Dickson, R. C. (1998) Annu. Rev. Biochem. 67, 27–482: Pewzner-Jung, Y., Ben-Dor, S., and Futerman, A. H. (2006) J. Biol. Chem. 281, 25001–250053: Mandon, E. C., Ehses, I., Rother, J., van Echten, G., and Sandhoff, K. (1992) J. Biol. Chem. 267, 11144–111484: Jeckel, D., Karrenbauer, A., Burger, K. N., van Meer, G., and Wieland, F. (1992) J. Cell Biol. 117, 259–2675: Futerman, A. H., Stieger, B., Hubbard, A. L., and Pagano, R. E. (1990) J. Biol. Chem. 265, 8650–86576: Huitema, K., van den Dikkenberg, J., Brouwers, J. F., and Holthuis, J. C. (2004) EMBO J. 23, 33–447: Yamaoka, S., Miyaji, M., Kitano, T., Umehara, H., and Okazaki, T. (2004) J. Biol. Chem. 279, 18688–186938: Ullman, M. D., and Radin, N. S. (1974) J. Biol. Chem. 249, 1506–15129: Voelker, D. R., and Kennedy, E. P. (1982) Biochemistry 21, 2753–275910: van Helvoort, A., van't Hof, W., Ritsema, T., Sandra, A., and van Meer, G. (1994) J. Biol. Chem. 269, 1763–176911: Muehlenberg, B. A., Sribney, M., and Duffe, M. K. (1972) Can J. Biochem. 50, 166–17312: Hannun, Y. A., and Obeid, L. M. (2002) J. Biol. Chem. 277, 25847–2585013: Wiegmann, K., Schutze, S., Machleidt, T., Witte, D., and Kronke, M. (1994) Cell 78, Spiegel, S., and Milstien, S. (2003) Nat. Rev. Mol. Cell Biol. 4, 397–40714: Ogretmen, B., and Hannun, Y. A. (2004) Nat. Rev. Cancer 4, 604–61615: Holthuis, J. C., Pomorski, T., Raggers, R. J., Sprong, H., and Van Meer, G. (2001) Physiol. Rev. 81, 1689–1723Protein Reference(s)Database Name: UniProt Accession number: Q9VS60 Species Accession: Human Safety Datasheet(s) for this product:NM_Sodium Azide/wp-content/uploads/SDS/Antibody SDS with Sodium Azide Noridic-MUbio.pdf

Noridic-Mubio是荷兰的一家著名的免疫学试剂生产厂商，因收购An Der Grub Bio Research GmbH(ADG)，增加了自己的产品线：全球最好的固定破膜剂FIX&PERM 。Nordic-Mubio严格遵照ISO9001标准生产高质量的抗体，主要为针对细胞粘附蛋白、核蛋白和骨架蛋白的抗体。同时Nordic-Mubio也是斑马鱼抗体开发的引领者之一，拥有50多种可用于斑马鱼免疫荧光检测的抗体。