Sulfatinibisanorallybioavailable,smallmoleculeinhibitorofvascularendothelialgrowthfactorreceptors(VEGFR)1,2,and3,andthefibroblastgrowthfactorreceptortype1(FGFR1),withpotentialantineoplasticandanti-angiogenicactivities.UponoraladmiNISTration,sulfatinibbindstoandinhibitsVEGFRsandFGFR1therebyinhibitingVEGFR-andFGFR1-mediatedsignaltransductionpathways.ThisleadstoareductionofangiogenesisandtumorcellproliferationinVEGFR/FGFR1-overexpressingtumorcells.ExpressionofVEGFRsandFGFR1maybeupregulatedinavarietyoftumorcelltypes.MedKooCat#:206205Name:SulfatinibCAS#:1308672-74-3ChemicalFormula:C24H28N6O3SExactMass:480.1944MolecularWeight:480.587ElementalAnalysis:C,59.98;H,5.87;N,17.49;O,9.99;S,6.67RelatedCAS#:1308672-74-3 1816307-67-1. Synonym:HMPL012;HMPL012;HMPL012;SulfatinibIUPAC/ChemicalName:N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamideInChiKey:TTZSNFLLYPYKIL-UHFFFAOYSA-NInChiCode:InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)SMILESCode:CC1=CC2=C(N1)C=CC(OC3=NC(NC4=CC(CS(NCCN(C)C)(=O)=O)=CC=C4)=NC=C3)=C2TechnicalDataAppearance:SolidpowderPurity:>98%(orrefertotheCertificateofAnalysis)ShippingCondition:Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.StorageCondition:Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).Solubility:SolubleinDMSO,notinwaterShelfLife:>2yearsifstoredproperlyDrugFormulation:ThisdrugmaybeformulatedinDMSOStockSolutionStorage:0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).HarmonizedSystemCode:293490AdditionalInformation     References