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NeoClone/RNA Pol II RPB1 Monoclonal Antibody- Ascites/W0011

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Details: Target InformationRPB1 is a 220kDa sub-unit of RNA Polymerase IIAlternate NamesRNA polymerase II sub-unit 1, RPB1, CTD repeat YSPTSPS, C- terminal domain repeat YSPTSPS, DNA-directed RNA polymerase II subunit A, RNA-directed RNA polymerase II subunit RPB1, POLR2A, POLR2HostMouseImmunogenPurified proteinRelevanceRPB1 is the largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. It forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.Reported Reactivitywheat, mouse, C. elegans, X. laevis

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Custom Antibodies

Who are we?

NeoClone is the Midwest’s premier custom antibody development company. We are committed to providing the highest quality antibodies for the global research and diagnostic markets while adding sophisticated new capabilities to bolster our entry into the therapeutic antibody market.

What do we do?

We make custom antibodies! Really good ones. Because no one method will work for every project, NeoClone will work with your team to develop the best antibody strategy, from initial project design through assay development, bringing a full set of tools to bear to antibody discovery, characterization, production, purification and screening. NeoClone offers a range of custom services and solutions to identify novel antibody reagents for you, utilizing multiple technology platforms, such as:

• Hybridoma (mouse monoclonal antibodies)

• Antibody phage display (scFv)

• Camelid antibodies (VHH)

• Antigen-specific B-Cell Enrichment (Reactivation)

Few companies have experience in both hybridoma and antibody phage display, much less single domain camelid antibody technologies. Add to that NeoClone’s patented antigen-specific B-cell enrichment process (Reactivation) for particularly rare targets and transgenic systems, and you can see why NeoClone is the best choice for maximum antibody diversity and affinity.

We view every project as a partnership, where the goals and results are dependent on the needs of our client.

You tell us what you need. We’ll make sure you get it.

Features and Benefits:

• NeoClone's wide array of custom antibody services are tailored to your specific requirements.

• Samples of antibodies are available to you throughout the process for evaluation in your laboratory.

• You receive regular progress reports as the project proceeds.

To learn more about our unique approach and how it can result in better antibodies please review the categories listed in this section. If you are interested in starting an antibody project with NeoClone, please contact us.