首页 > NeoClone > NeoClone/RNA Pol II RPB4 Monoclonal Antibody/W0013

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NeoClone/RNA Pol II RPB4 Monoclonal Antibody/W0013

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Details: Target InformationRPB4 is a 32kDa subunit of RNA Polymerase IIAlternate NamesB32, DNA-directed RNA polymerase II 32 kDa polypeptide, RNA polymerase II subunit B4HostMouseImmunogenRecombinant ProteinRelevancePol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA from entering the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay.Reported ReactivityNone

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Custom Antibodies

Who are we?

NeoClone is the Midwest’s premier custom antibody development company. We are committed to providing the highest quality antibodies for the global research and diagnostic markets while adding sophisticated new capabilities to bolster our entry into the therapeutic antibody market.

What do we do?

We make custom antibodies! Really good ones. Because no one method will work for every project, NeoClone will work with your team to develop the best antibody strategy, from initial project design through assay development, bringing a full set of tools to bear to antibody discovery, characterization, production, purification and screening. NeoClone offers a range of custom services and solutions to identify novel antibody reagents for you, utilizing multiple technology platforms, such as:

• Hybridoma (mouse monoclonal antibodies)

• Antibody phage display (scFv)

• Camelid antibodies (VHH)

• Antigen-specific B-Cell Enrichment (Reactivation)

Few companies have experience in both hybridoma and antibody phage display, much less single domain camelid antibody technologies. Add to that NeoClone’s patented antigen-specific B-cell enrichment process (Reactivation) for particularly rare targets and transgenic systems, and you can see why NeoClone is the best choice for maximum antibody diversity and affinity.

We view every project as a partnership, where the goals and results are dependent on the needs of our client.

You tell us what you need. We’ll make sure you get it.

Features and Benefits:

• NeoClone's wide array of custom antibody services are tailored to your specific requirements.

• Samples of antibodies are available to you throughout the process for evaluation in your laboratory.

• You receive regular progress reports as the project proceeds.

To learn more about our unique approach and how it can result in better antibodies please review the categories listed in this section. If you are interested in starting an antibody project with NeoClone, please contact us.