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Peptides/Peptides International/2µg/CYT-618-2µg
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Product Code: CYT-618Synonyms/Product Alternate Names: Clusterin Canine Recombinant, HEKCLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, MGC24903, Clusterin, Glycoprotein 80, Gp80, CLU.Clusterin mRNA and Clusterin protein are shown to increase with androgen treatment. Binding of clusterin to the LDL-Receptor plays a role in the pathogenesis of membranous glomerulonephritis. Clusterin is down regulated in CaP in association with matched benign controls. Clusterin is involved in cellular senescence and tumorigenesis. Clusterin is involved in photo-oxidative cell death pathway. Clusterin is a functional tumor marker for the diagnosis of pediatric large cell lymphoma. Clusterin is activated in low pH. Clusterin is involved in the inhibition of NF-kappaB signaling through stabilization of IkappaBs thus results in suppression of tumor cell motility. N-terminal deletion of clusterin is vital for its alterations of biogenesis in esophageal squamous cell carcinoma.Clusterin Canine Recombinant produced in HEK293 cells is a glycosylated, Polypeptide chain containing 436 amino acids and having a molecular mass of 50.72 kDa. The protein is fused with 13 amino acid Flag tag at N-Terminus.The Apolipoprotein-J Canine is purified by proprietary chromatographic techniques.Canine Clusterin was filtered (0.4µm) and lyophilized from 0.5mg/ml solution containing 20mM Tris buffer and 20mM NaCl, pH 7.5.Origin: Human Embryonic Kidney 293 Cells.Storage Conditions: -20 °CPurity: Greater than 95% as determined by SDS PAGE.One-Letter Code:PGDYKDDDDK PAGDQAVSDT ELQEMSTEGS KYINKEIKNA LKGVKQIKTL IEQTNEERKS LLSNLEEAKK KKEDALNDTK DSETKLKASQ GVCNDTMMAL WEECKPCLKQ TCMKFYARVC RSGSGLVGHQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ THALDVMQDS FNRASSIMDE LFQDRFFTRE PQDTYHYDelivery Details: All quantities are subject to availability. Please allow 7-10 days for delivery.Custom QuoteBulk Qty Request FormView All Recombinant ProteinsPeptides International Certified To ISO 9001:2015© 2020 Peptides International. All rights reserved.Sitemap Site Info Contact Links NewsADS/CofAOOHnado_blizzardCreated with Sketch.
现代营养学研究发现:人类摄食蛋白质经消化道的酶作用后,大多是以低肽形式消化吸收的,以游离氨基酸形式吸收的 比例很小。进一步的试验又揭示了肽比游离氨基酸消化更快、吸收更多,表明肽的生物效价和营养价值比游离氨基酸更高。这也正是活性肽的无穷魅力所在。
生物活性肽(Bioact ive Peptide s ,BA P)就是对生物机体的生命活动有益或是具有生理作用的肽类化合物, 是一类相对分子质量小于6000Da , 具有多种生物学功能的多肽。其分子结构复杂程度不一,是介于氨基酸与蛋白质之间的分子聚合物,小至由两个氨基酸组成,大至由数十个氨基酸通过肽键连接而成,而且这些多肽可通过磷酸化、糖基化或酰基化而被修饰 [1]  。
生物活性肽有多种多样的生理功能, 如激素作用、免疫调节、抗血栓、抗高血压、降胆固醇、抑菌、抗病毒、抗癌作用等 [2]  。这些功能是原蛋白质或组成氨基酸所不具备的独特的生理机能, 且许多活性肽的组成氨基酸并不一定是必需氨基酸,这就为利用蛋白质资源, 特别是那些原本认为生物效价不高的蛋白质资源利用提供了新的机遇,是当前国际食品界最热门的研究课题和极具发展前景的功能因子。20世纪末,科学家在破解基因的秘密的同时,也对存在于生物体内的另一类奇妙物质的研究发生极大的兴趣。这类物质就是生物活性,或称功能肽,由氨基酸组成,是一种小分子的蛋白质,比如胰岛素,就是一种多肽,再如在日本应用广泛的促进钙吸收的CCP,在欧美风靡一时的促进生长的HGH……。
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