DescriptionCultrex®BasementMembraneExtract(BME)isasolubleformofbasementmembranepurifiedfromEngelbreth-Holm-Swarm(EHS)tumor.Thisextractprovidesanaturalextracellularmatrixhydrogelthatpolymerizesat37°Ctoformareconstitutedbasementmembrane.Basementmembranesarecontinuoussheetsofspecializedextracellularmatrixthatformaninterfacebetweenendothelial,epithelial,muscle,orneuronalcellsandtheiradjacentstromaandthatplayanessentialroleintissueorganizationbyinfluencingcelladhesion,migration,proliferation,anddifferentiation.ThemajorcomponentsofBMEincludelaminin,collagenIV,entactin,andheparinsulfateproteoglycans.TheCultrex®BME CellInvasionAssayprovidesatoolforassessingcellinvasionthroughareconstitutedbasementmembraneandisavailablein24and96wellformats.Catalog#3455-024-Kincludes:CatalogNumberDescriptionQty3455-096-025XBMECoatingSolution13455-096-0310XCoatingBuffer14892-010-01CalceinAM13455-024-01CellInvasionInserts13455-096-0425XCellWashBuffer13455-096-0510XCellDissociationSolution1Catalog#3455-096-Kincludes:CatalogNumberDescriptionQty3455-096-025XBMECoatingSolution13455-096-0310XCoatingBuffer14892-010-01CalceinAM13455-096-01CellInvasionChamber13455-096-0425XCellWashBuffer13455-096-0510XCellDissociationSolution1HypermethylationoftheGABREtextasciitildemiR-452textasciitildemiR-224PromoterinProstateCancerPredictsBiochemicalRecurrenceafterRADIcalProstatectomy,HelleKristensen,ChristaHaldrup,SiriStrand,KamillaMundbjerg,MartinM.Mortensen,KasperThorsen,MarieStampeOstenfeld,PeterJ.Wild,ChristianArsov,WolfgangGoering,TapioVisakorpi,LarsEgevad,JohanLindberg,HenrikGrönberg,SørenHøyer,MichaelBorre,TorbenF.Ørntoft,andKarinaD.SørensenClin.CancerRes.,Apr2014;20:2169–2181.http://clincancerres.aacrjournals.org/cgi/content/abstract/20/8/21691α,25-DihydroxyvitaminD3InhibitsEsophagealSquamousCellCarcinomaProgressionbyReducingIL6SignalingPing-TsungChen,Ching-ChuanHsieh,Chun-TeWu,Tzu-ChenYen,Paul-YangLin,Wen-ChengChen,andMiao-FenChenMol.CancerTher.,Jun2015;14:1365–1375.http://mct.aacrjournals.org/cgi/content/abstract/14/6/1365ReciprocalregulationofaminoacidimportandepigeneticstatethroughLat1andEZH2StephenGDann,MichaelRyskin,AnthonyMBarsotti,JonathonGolas,CelineShi,MiriamMiranda,ChristineHosselet,LuannaLemon,JudyLucas,MahaKarnoub,FangWang,JeremySMyers,ScottJGarza,MaximillianTFollettie,KennethGGeles,AnkeKlippel,RobertARollins,andValeriaRFantinEMBOJ.,Jul2015;34:1773–1785.http://EMBOJ.embopress.org/cgi/content/abstract/34/13/1773“Semaphorin3DautocrinesignalingmediatesthemetastaticroleofannexinA2inpancreaticcancer”“KellyFoley,AgnieszkaA.Rucki,QianXiao,DongerZhou,AshleyLeubner,GuanglanMo,JenniferKleponis,AnnieA.Wu,RajniSharma,QingguangJiang,RobertA.Anders,ChristineA.Iacobuzio-Donahue,KatherineA.Hajjar,AnirbanMaitra,ElizabethM.Jaffee,andLeiZheng”Sci.Signal.,Aug2015;8:ra77.http://stke.sciencemag.org/cgi/content/abstract/sigtrans;8/388/ra77EukaryoticTranslationInitiationFactor5A(EIF5A)RegulatesPancreaticCancerMetastasisbyModulatingRhoAandRho-associatedKinase(ROCK)ProteinExpressionLevelsKenFujimura,SunkyuChoi,MeghanWyse,JanStrnadel,TracyWright,andRichardKlemkeJ.Biol.Chem.,Dec2015;290:29907–29919.http://www.jbc.org/cgi/content/abstract/290/50/29907“ExtracellularandLuminalpHRegulationbyVacuolarH+-ATPaseIsoformExpressionandTargetingtothePlasmaMembraneandEndosomes”GinaA.Smith,GarethJ.Howell,ClairPhillips,StephenP.Muench,SreenivasanPonnambalam,andMichaelA.HarrisonJ.Biol.Chem.,Apr2016;291:8500–8515.http://www.jbc.org/cgi/content/abstract/291/16/8500TheMCT4Gene:ANovel,PotentialTargetforTherapyofAdvancedProstateCancer“StephenYiuChuenChoi,HuiXue,RebeccaWu,LadanFazli,DongLin,ColinC.Collins,MartinE.Gleave,PeterW.Gout,andYuzhuoWang”Clin.CancerRes.,Jun2016;22:2721–2733.http://clincancerres.aacrjournals.org/cgi/content/abstract/22/11/2721