DescriptionProductAvailABIlity:InStock(deliverywithin2-3businessdays,noextrachargefordrop-shipping).Ordering:ToplaceanorderviacreditcardorPOuseAddtoCartbutton(creatinganaccountisnotrequired).Kidney InVivoTransfectionReagentsiRNAand DNA kidney invivodeliveryreagentforanimalresearch(mouse,rat)ModesofadmiNISTration:Systemicintravenous(i.v.)injectionDirectintratumoral(i.t.)injectionIntraperitoneal(i.p.)injectionKidney-targeted InVivoTransfectionReagentNanoparticle-basedLiposomalreagentNanoparticle/liposomeconjugatedcomplexesarestableinserum(16h)Efficientdeliverytothe kidneytissue(viasystemicadministration)and kidneytumors(viaintratumoraladministration)EfficientsiRNA,shRNA,microRNA,andplasmidDNAdeliveryMinimaltoxicityFunctionallyvalidatedinmiceApplicableforplasmidDNA/siRNAco-injectionDownloadKidney-targeted invivotransfectionprotocol:[PDF][Word]DownloadPowerPointpresentationforKidney-targetedinvivotransfectionkit:[PPT]DevelopedandmanufacturedbyAltogenBiosystemsDATAFigure1.Systemicadministration(i.v.)ofKidneyInVivoTransfectionReagentconjugatedwith80ugofchemicallymodifiedsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.Tissues(Liver,Brain,Muscle,Kidney,Tumor,Heart,Spleen,Lung)werecollectedandRNAisolated24hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=7).Figure2.Intratumoraladministration(i.t.)ofKidneyInVivoTransfectionReagentconjugatedwith80ugofchemicallymodifiedsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.AnimalmodelisNOD/SCIDxenograftmousebearingflanktumorofhumanorigin(kidneycancercellline).Tissues(Liver,Brain,Muscle,Kidney,Tumor,Heart,Spleen,Lung)werecollectedandRNAisolated24hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=7).Figure3. Systemicadministration(i.v.)ofKidneyInVivoTransfectionReagentconjugatedwith80ugofchemicallymodifiedsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.Tissues(Liver,Brain,Muscle,Kidney,Tumor,Heart,Spleen,Lung)werecollectedandtotalproteinfractionisolated72hoursafterfirstinjection.SampleswereanalyzedbyWesternBlotAnalysisforLaminA/Cgeneexpressionlevels.KidneyTransfectionReagent citationreferences:TheJournalofPathology.2015235(5):731–744.BDNFrepairspodocytedamagebymicroRNA-mediated…MinLietal[PDF] NatureCommunications.2016.7:12076.miR-93regulatesMsk2-mediatedchromatinremodellingindiabeticnephropathy.Badaletal[PDF] JournaloftheAmericanSocietyofNephrology.2016Nov;27(11):3308-3319.SynaptopodinLimitsTRPC6PodocyteSurfaceExpressionandAttenuatesProteinuria.YuHetal[PDF]BritishJournalofCancer.2012 107(3):516-26.TIGARinducesp53-mediatedcell-cycle…Madanetal[PDF]Circulation Research.201015;107(8).Kruppel-likefactor-4transcriptionallyregulates…Cowanetal[PDF]J TranslMed.201015;8:133.Preventionofhyperglycemia-inducedmyocardialapoptosis…Zhangetal[PDF]RequestaQuoteforKidneyInVivoTransfectionKitAltogenResearchServices:AltogenLabsprovidesGLP-compliantcontractresearchstudiesforpre-clinicalresearch,INDapplications,anddrugdevelopment.BIOLOGyCROservices include:Xenograftmodels(60+),developmentofstablecelllines,ELISAassaydevelopment,cell-basedandtissuetargetedRNAistudies,safetypharm/toxassays,andotherstudies(visitAltogenLabs.com).VolumeOptions:0.5ml–10injections(Catalog#5070)1.5ml–30injections(Catalog#5071)8.0ml–160injections(Catalog#5072)
Altogen Biosystems全国代理部分产品列表：
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货号
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产品
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规格
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价格（美元）
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5030
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1703
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A204 Transfection Reagent (Rhabdomyosarcoma)
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0.5ml
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170
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1704
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A204 Transfection Reagent (Rhabdomyosarcoma)
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1.5ml
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348
窗体顶端
窗体底端
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2101
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A204 Transfection Reagent (Rhabdomyosarcoma)
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1.5ml CRISPR
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548
窗体顶端
窗体底端
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7018
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A204 Transfection Reagent (Rhabdomyosarcoma)
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8.0ml
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1044
窗体顶端
窗体底端
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1167
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A375 Cells Transfection Reagent (CRL-1619)
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0.5ml
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195
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1168
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A375 Cells Transfection Reagent (CRL-1620)
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1.5ml
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427
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2102
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A375 Cells Transfection Reagent (CRL-1621)
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1.5ml CRISPR
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627
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1169
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A375 Cells Transfection Reagent (CRL-1622)
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8.0ml
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1281
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5030
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Nanoparticle In Vivo Transfection Reagent
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0.5 ml - 10 injections
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445
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5010
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LIPID In Vivo Transfection Reagent
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0.5 ml - 10 injections
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405
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5040
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PEG-Liposome In Vivo Transfection Reagent
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0.5 ml - 10 injections
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465
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5020
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POLYMER In Vivo Transfection Reagent
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0.5 ml - 10 injections
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425
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5050
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Pancreas In Vivo Transfection Kit
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0.5 ml - 10 injections
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495
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5060
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Liver In Vivo Transfection Kit
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0.5 ml - 10 injections
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495
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5070
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Kidney In Vivo Transfection Kit
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0.5 ml - 10 injections
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495
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1721
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BMS2 Transfection Reagent (Bone Marrow Cells)
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0.5 ml
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231
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6345
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C6 Transfection Reagent (Glioma Cells, CCL-107)
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0.5 ml
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199
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6803
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DLD-1 Transfection Reagent (Colon Cancer, CCL-221)
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0.5 ml
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201
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1775
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HUH-7 Transfection Reagent (Liver Cancer Cells)
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0.5 ml
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179
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