首页 > Echelon > Echelon/Tensin 4 VHH Antibody/250 ug/Z-N010

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Echelon/Tensin 4 VHH Antibody/250 ug/Z-N010

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Z-N010

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4000-520-616

产品说明

Recombinant anti-Tensin 4 Nanobody, Clone # Nb12, COOH-terminal HA tag.Type: VHH single domainSource: E. ColiApplications: ELISA, Immunoprecipitation, Pull downClonality: MonoclonalBackground: Tensin 4 VHH Antibody was produced in an llama with a fragment of Tensin4 encompassing residues 428-714 then cloned for recombinant production in E. Coli. Tensin, aka TNS4 or CTEN, is a component of the cytoskeleton and localizes close to or at focal adhesions, connecting the cytoplasmic tail of integrins with actin filaments. It contains a C-terminal SH2 and PTB (phosphotyrosine binding domain) and binds tyrosine-phosphorylated proteins that assemble into signaling complexes at focal adhesions. Its expression has been reported to be down regulated in prostate cancer, but upregulated in lung and breast cancer.Recombinant anti-Tensin 4 Nanobody 12 was developed by Gulliver Biomed.StorageStore at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.Publications1) Bertier L, et al. (2018) Nanobodies targeting cortactin proline rich, helical, and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells. Biomed Pharmacother; 102:230-2412) Van Audenhove I, et al. (2016) Nanobodies as versatile tools to understand, diagnose, visualize, and treat cancer. EBioMedicine; 8:40-48Keywords: Tensin 4, CTEN, TNS4, nanobody, VHH, antibody, single domain‘Nanobody’ and ‘nanobodies’ are registered trademarks of Ablynx N.V.CategoriesAntibodies & ProteinsFilterAntibody, Nanobody

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