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Echelon/PI(3,4)P2 diC16/1 mg/P-3416

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P-3416

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产品说明

PI(3,4)P2 diC16 (Phosphatidylinositol 3,4-bisphosphate diC16) is a synthetic, purified dipalmitoyl PI(3,4)P2.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.Product Keywords: Dipalmitoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 (16:0/16:0), PI(3,4)P2 C16, or PI34P2.Bulk discounts available, please email echelon@echelon-inc.com for details.Publication Powered by Bioz See more details on Bioz1. Dowler, S., R. A. Currie, et al. (1999). “DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.” Biochem J 342(Pt 1): 7-12.2. Karathanassis, D., R. V. Stahelin, et al. (2002). “Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4- bisphosphate and phosphatidic acid is masked by an intramolecular interaction.” Embo J 21(19): 5057-68.3. Stampoulis, P., T. Ueda, et al. (2012). “Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR.” J Biol Chem(287): 17848-17859.4. Ivarsson, Y., et al. (2013). “Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments.” PLoS ONE 8(2): e54581.5. Aksnes, H., et al. (2017). “Molecular Determinants of the N-Terminal Acetyltransferase Naa60 Anchoring to the Golgi Membrane.” The Journal of biological chemistry 292: 6821-6837.CategoriesLipidsFilterdiC16, Phosphoinositides, PI(3,4)P2CAS Number183623-41-8Molecular FormulaC41H76Na5O19P3Molecular Weight (g/mol)1,080.9Purity>95%Storage-20 °C or below

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