产品说明
CatalogNo.: P-3416MW: 1080.9CAS: 183623-41-8Description: Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol3,4-bisphosphate(PI(3,4)P2)isproducedinstimulatedcellsbytheactionofphosphatidylinositol3-kinases(PI3Ks)and/orlipidphosphatases(SHIP,TPTE,etc.).PI(3,4)P2bindsthepleckstrinhomology(PH)-domainofAKT/PKBleADIngtocellsurvivalanditalsohasanimportantroleinpodosomeformationnearfocaladhesions.Storage-20°CFeaturedinPublication:1)Dowler,S.,R.A.Currie,etal.(1999)."DAPP1:adualadaptorforphosphotyrosineand3-phosphoinositides."BiochemJ342(Pt1):7-12.2)Karathanassis,D.,R.V.Stahelin,etal.(2002)."BindingofthePXdomainofp47(phox)tophosphatidylinositol3,4-bisphosphateandphosphatidicacidismaskedbyanintramolecularinteraction."EmboJ21(19):5057-68.3)Stampoulis,P.,T.Ueda,etal.(2012)."Atypicalmembrane-embeddedPI(3,4)P2bindingsiteonp47phoxPXdomainrevealedbyNMR."JBiolChem(287):17848-17859.ProductKeywords:DioctanoylPhosphatidylinositol3,4-bisphosphate,PtdIns(3,4)P2,PI(3,4)P2,orPI34P2.
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