首页 > Echelon > echelon-inc/Phosphatidylinositol 3,5-bisphosphate diC8 (PI(3,5)P2 diC8)/1mg/P-3508-1mg

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echelon-inc/Phosphatidylinositol 3,5-bisphosphate diC8 (PI(3,5)P2 diC8)/1mg/P-3508-1mg

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P-3508-3

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CatalogNo.: P-3508MW: 856.48CAS: 299216-96-6Description: Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol3,5-bisphosphateisinverylowabundanceandisrequiredforretrogrademembranetraffickingfromlysosomalandlateendosomalcompartmentstotheGolgiandisinvolvedinautophagy.PI(3,5)P2levelsarecontrolledbythe5-kinasePIKfyveandthe5-phosphataseFig4/Sac3anddisregulationislinkedtoseveralhumanneuropathies(egChacot-Marie-Toothdisease).Storage-20°CFeaturedinPublications:1)Marcus,S.L.,M.R.Wenk,etal.(2001)."Asynaptojanin-homologousregionofSalmonellatyphimuriumSigDisessentialforinositolphosphataseactivityandAktactivation."FEBSLett494(3):201-72)Johnson,L.M.,K.M.James,etal.(2005)."IdentificationofKeyResiduesintheA-RafKinaseImportantforPhosphoinositideLipidBindingSpecificity."Biochemistry44(9):3432-3440.3)Ikonomov,O.C.,D.Sbrissa,etal.(2009)."Sac3isaninsulin-regulatedphosphatidylinositol3,5-bisphosphatephosphatase:gainininsulinresponsivenessthroughSac3down-regulationinADIpocytes."JBiolChem284(36):23961-71.ProductKeywords:DioctanoylPhosphatidylinositol3,5-bisphosphate,PtdIns(3,5)P2,PI(3,5)P2

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