首页 > Echelon > echelon-inc/Phosphatidylinositol 3,4,5-trisphosphate diC4 (PI(3,4,5)P3 diC4)/1mg/P-3904-1mg

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echelon-inc/Phosphatidylinositol 3,4,5-trisphosphate diC4 (PI(3,4,5)P3 diC4)/1mg/P-3904-1mg

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P-3904-3

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CatalogNo.: P-3904MW: 868.21Description: Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol3,4,5-trisphosphate(PIP3),formedfromPI(4,5)P2thoughphosphorylationbyPI3-kinase,activatesnumeroussignalingpathwaysresultingincellproliferation,growth,survival,glucosetransportandproteinsynthesis.HighPIP3levelsfromdisregulationofPI3-Khavebeendemonstratedincancerandinflammatorydiseases.PIP3ishydrolyzedbythephosphatasesPTENtoPI(4,5)P2andSHIPtoPI(3,4)P2.StorageFeaturedinPublications1)Thapar,R.,A.E.Karnoub,etal.(2002)."StructuralandbiophysicalinsightsintotheroleoftheinsertregioninRac1function."Biochemistry41(12):3875-83.2)He,J.,R.M.Haney,etal.(2008)."MolecularmechanismofmembranetargetingbytheGRP1PHdomainboxs."JLipidRes49(8):1807-15.3)Lumb,C.N.,J.He,etal.(2011)."BiophysicalandcomputationalstudiesofmembranepenetrationbytheGRP1pleckstrinhomologydomain."Structure19(9):1338-46.ProductKeywords:DibutanoylPhosphatidylinositol3,4,5-trisphosphate,PtdIns(3,4,5)P3,PI(3,4,5)P3,orPIP3

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