首页 > Echelon > echelon-inc/Phosphatidylinositol 3,4,5-trisphosphate diC8 (PI(3,4,5)P3 diC8)/500ug/P-3908-500ug

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echelon-inc/Phosphatidylinositol 3,4,5-trisphosphate diC8 (PI(3,4,5)P3 diC8)/500ug/P-3908-500ug

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P-3908-2

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CatalogNo.: P-3908MW: 980.42CAS: 163563-77-7Description: Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol3,4,5-trisphosphate(PIP3),formedfromPI(4,5)P2thoughphosphorylationbyPI3-kinase,activatesnumeroussignalingpathwaysresultingincellproliferation,growth,survival,glucosetransportandproteinsynthesis.HighPIP3levelsfromdisregulationofPI3-Khavebeendemonstratedincancerandinflammatorydiseases.PIP3ishydrolyzedbythephosphatasesPTENtoPI(4,5)P2andSHIPtoPI(3,4)P2.Storage-20°CFeaturedinPublications1)Paternotte,N.,J.Zhang,etal.(2005)."SHIP2interactionwiththecytoskeletalproteinVinexin."FEBSJ272(23):6052-66.2)Odriozola,L.,G.Singh,etal.(2007)."RegulationofPTENactivitybyitscarboxyl-terminalautoinhibitorydomain."JBiolChem282(32):23306-15.3)Hubbard,L.L.,C.A.Wilke,etal.(2011)."PTENLimitsAlveolarMacrophageFunctionAgainstPseudomonasaeruginosaFollowingBoneMarrowTransplantation."AmJRespirCellMolBiol45(5):1050-1058.ProductKeywords:DioctanoylPhosphatidylinositol3,4,5-trisphosphate,PtdIns(3,4,5)P3,PI(3,4,5)P3,orPIP3

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