首页 > Echelon > echelon-inc/Phosphatidylinositol 3,4,5-trisphosphate diC16 (PI(3,4,5)P3 diC16)/1mg/P-3916-1mg

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echelon-inc/Phosphatidylinositol 3,4,5-trisphosphate diC16 (PI(3,4,5)P3 diC16)/1mg/P-3916-1mg

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P-3916-3

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CatalogNo.: P-3916MW: 1204.84CAS: 165689-82-7Description: Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol3,4,5-trisphosphate(PIP3),formedfromPI(4,5)P2thoughphosphorylationbyPI3-kinase,activatesnumeroussignalingpathwaysresultingincellproliferation,growth,survival,glucosetransportandproteinsynthesis.HighPIP3levelsfromdisregulationofPI3-Khavebeendemonstratedincancerandinflammatorydiseases.PIP3ishydrolyzedbythephosphatasesPTENtoPI(4,5)P2andSHIPtoPI(3,4)P2.Storage-20°CFeaturedinPublications:1)Weiner,O.D.,P.O.Neilsen,etal.(2002)."APtdInsP(3)-andRhoGTPase-mediatedpositivefeedbackloopregulatesneutrophilpolarity."NatCellBiol4(7):509-13.2)Merlot,S.,R.Meili,etal.(2003)."APTEN-related5-phosphatidylinositolphosphataselocalizedintheGolgi."JBiolChem278(41):39866-73.3)Shenker,B.J.,M.Dlakic,etal.(2007)."Anovelmodeofactionforamicrobial-derivedimmunotoxin:thecytolethaldistendingtoxinsubunitBexhibitsphosphatidylinositol3,4,5-triphosphatephosphataseactivity."JImmunol178(8):5099-108.4)Horikoshi,Y.,S.Hamada,etal.(2011)."Phosphoinositidebindingbypar-3involvedinpar-3localization."CellStructFunct36(1):97-102.ProductKeywords:DipalmitoylPhosphatidylinositol3,4,5-trisphosphate,PtdIns(3,4,5)P3,PI(3,4,5)P3,orPIP3

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