首页 > Echelon > echelon-inc/Biotin Phosphatidylinositol 4,5-bisphosphate/50ug/C-45B6-50ug

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echelon-inc/Biotin Phosphatidylinositol 4,5-bisphosphate/50ug/C-45B6-50ug

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C-45B6-2

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CatalogNo.: C-45B6MW: 1154.84Description: WatersolubleanalogofPI(4,5)P2(PIP2)labeledwithbiotinatthesn-1position.Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol4,5-bisphosphate(PIP2)hasbeenshowntoplayacentralroleinavarietyofcellularfunctions.Amongstitsmanyfunctions,PIP2isasubstrateforPhospholipaseC-coupledG-proteinpathwaysinvolvedinintracellularcalciumreleaseinanumberoftissues.ItisalsoasubstrateforclassIphosphoinositide3-kinase(PI3-K)formingPI(3,4,5)P3.Storage-20°CFeaturedinReferences1)Rzepecki,P.W.andG.D.Prestwich(2002)."Synthesisofhybridlipidprobes:derivativesofphosphatidylethanolamine-extendedphosphatidylinositol4,5-bisphosphate(Pea-PIP(2))."JOrgChem67(16):5454-60.2)Goksoy,E.,Y.-Q.Ma,etal.(2008)."StructuralBasisfortheAutoinhibitionofTalininRegulatingIntegrinActivation."Molecularcell31(1):124.3)Michailidis,I.,R.Rusinova,etal.(2011)."Phosphatidylinositol-4,5-bisphosphateregulatesepidermalgrowthfactorreceptoractivation."PflugersArchivEuropeanJournalofPhysiology461(3):387.4)A.L.Egea-Jimenez,R.Gallardo,A.Garcia-Pino,Y.Ivarsson,A.M.Wawrzyniak,R.Kashyap,R.Loris,J.Schymkowitz,F.RousseauandP.Zimmermann.(2016)"Frizzled7andPIP2bindingbysynteninPDZ2domainsupportsFrizzled7traffickingandsignalling"NatCommun7,DOI:10.1038/ncomms12101

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