产品说明
CatalogNo.: B-0061MW: 372.18CAS: 449173-19-7Description: Sphingosine-1-phosphate(S1P)isaversatilesignalingmolecule,whichisproducedbyphosphorylationofsphingosinebytwodistinctsphingosinekinases,SphK1andSphK2.S1PbindstofiveG-proteincoupledreceptorsdesignatedS1P1-5leADIngtocellproliferation,motility,survival,andhasaroleinregulationcellshapeandCa2+homeostasis.VPC23019,ananalogofFTY720(Fingolimod,Gilenya),isapotentanatagoNISToftheS1P1&S1P3receptors.VPC23019willinhibitthemigrationofvarioustypesofcancercells.Storage-20°CorbelowReferences1)M.D.Davis,J.J.Clemens,T.L.Macdonald,etal.“Sphingosine1-phosphateanalogsasreceptorantagonists.”TheJournalofBIOLOGicalChemisty,280(2005),9833-9841.2)R.J.Watters,H-G.Wang,etal.“TargetingSphingosine-1-PhosphateReceptorsinCancer”AnticancerAgentsMedChem.,11(2011),810-817.
Echelon产品线
★合成磷脂、磷酸肌醇、鞘脂及其衍生物 |
★脂蛋白质相互作用工具 |
★脂质含量检测试剂盒 ★脂质相关生物酶活性检测，抑制剂筛选试剂盒 |
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