首页 > haemtech > Haematologic Technologies/Human Angiostatin - Haematologic Technologies, Inc./ANG-01/ANG-01-500µg

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Haematologic Technologies/Human Angiostatin - Haematologic Technologies, Inc./ANG-01/ANG-01-500µg

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ANG-01-500µg

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Angiostatin is a single-chain, proteolytic fragment of glu-plasminogen which has a molecular weight of about 38,000. It is a potent inhibitor of angiogenesis and was first identified and isolated from the serum and urine of tumor bearing mice (1). The mouse protein reportedly extends from threonine-98 through valine-440 (numbering from the NH2-terminus of glu-plasminogen). This fragment of mouse plasminogen, as well as the human equivalent, includes four out of the five kringle domains of plasminogen (1).The inhibition of angiogenesis by angiostatin is directly related to inhibiting the proliferation of endothelial cells (1,2). Because tumor growth is known to be angiogenesis dependent, it was initially hypothesized that the inhibitory properties of angiostatin would have clinical utility in arresting various cancers that are expressed as solid tumors. Studies performed in animal model systems have since demonstrated that recombinant angiostatin effectively suppresses tumor growth and metastasis (3,4).Numerous enzymes have been identified which will convert plasminogen to angiostatin or at least to angiostatin-like fragments. The enzymes include several matrix metalloproteinases as well as urokinase and a tumor cell-derived reductase (5-10). The precise enzyme or mechanism which is responsible for the formation of angiostatin in vivo is unknown and it is believed that there may be multiple pathways for the conversion of plasminogen to angiostatin.Structure/function studies have indicated that the first three kringle domains (and not the fourth) are responsible for the inhibitory properties of angiostatin, and that removal of the fourth kringle domain may actually yield a more potent inhibitor (11).HTI’s "angiostatin" product is produced by limited proteolysis of purified human glu-plasminogen using a proprietary enzyme preparation. The NH2-terminal sequence of this fragment is identical to human glu-plasminogen (Glu-1) and the molecule terminates at proline-452 thus making it larger than the "natural" or elastase derived product with an apparent molecular weight of about 50,000. Like authentic angiostatin, this product demonstrates an antiproliferative effect when tested in a growth factor-induced endothelial cell proliferation assay. The product is formulated in 20mM Hepes, 0.15M NaCl, pH 7.4, and should be stored frozen at -70oC or below.

Haematologic Technologies是一家通过ISO 9001：2015认证的公司，是一家主要制造商，专门从事旨在用于体外研究的高质量血浆蛋白的分离和表征的主要制造商。HT的重点是参与凝血级联反应的蛋白质，以及骨代谢的调节。HT产品系列包括150多种高度纯化且特性良好的蛋白质，包括酶原，酶，辅因子和抑制剂，以及单克隆和多克隆抗体的互补产品系列。还提供因子不足的血浆和定制的用于临床研究的定制采血管。提供的服务包括定制蛋白质纯化，蛋白质修饰，分析开发，合同制造和合同研究。