ETEAKYYRTLEDIEC, internal region|Control peptide corresponding to polyclonal antibody, Catalog#V2121-11A, goat x human.||Vav2 is an oncoprotein member of the Dbl family of proteins that serves as a guanine nucleotide exchange factor (GEF) for the Rho family of Ras-related GTPases (1). Vav2 possesses a C-terminal pleckstrin homology (PH) domain and a tandem Dbl homology (DH) domain which interacts with Rho family GTPases to catalyze GDP release (1-2). The PH|domain serves as a negative regulator of DH domain GEF activity, which is promoted by phosphatidylinositol 4, 5-phosphate (PIP2) and is antagonized by the PI3K product, phosphatidylinositol3, 4, 5-phosphate (PIP3) (3). Hence, PI3K may facilitate the activation of Vav. Vav2 also contains a cysteine-rich domain (CRD) that is a positive modulator for DH|domain function (4). Vav2 is widely expressed in human tissues (5-6). The SH2 domain of Vav2 associates with the receptor tyrosine kinases EGFr (7-9) and PDGFr (8), binding preferentially to the phosphorylated residues pTyr-992 and pTyr-1148 of EGFr (10) and directly to multiple autophosphorylation sites of PDGFr (8). Overexpression of Vav2 has been shown to be sufficient to activate its oncogenic potential (6). In ovarian tumor cells, the binding of hyaluronan to its receptor (CD44v3) and the recruitment of Grb2 and p185HER2 to the CD44v3-Vav2 complex activates Vav2-mediated Rac1 and Ras signaling, leading to ovarian tumor cell migration and growth.||Application(s):|Suitable for use in Peptide ELISA. Other applications have not been tested. ||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.||Peptide Blocking (see corresponding antibody V2121-11A):|Antibodies are typically supplied at 0.5mg/ml and peptides as a 100ul pellet. When peptides are reconstituted in 200ul water, the concentration would be also 0.5mg/ml. To start, the best ratio would be 1:1 (which means molar excess of peptides relative to antibodies when identical volumes are mixed). Mix equal volumes of peptide and antibody at the required dilution and leave at ambient temperature. It is best is to have two identical blots, to be incubated with equal amount of antibodies, but one with the antibodies pre-adsorbed to the peptide for 20min. Then incubate and develop the two blots in parallel.

USBIo全称United States BIOLOGical，位于麻省斯万普斯科特(Swampscott, MA)。全美**的抗原抗体和生化试剂供应商，目前向全球六十余个国家的科研工作者提供约50,000种抗体、抗原和生化试剂，以质量**闻名。主要产品种类包括：抗体、生化试剂、基因克隆相关产品、培养基、生长因子等细胞因子、分子生物学试剂。美国US Biological公司是生物化学和生物学试剂的专业生产商，产品服务于免疫学，分子生物学，分子遗传学，体外诊断，组织培养等科研领域。产品精确度高，质量稳定，产品数量巨大，提供70,000多种抗体、抗原和生化试剂等。

Usbio的生物化学品，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。USBio产品从经济实惠的研究数量到更大的批量可用于工艺开发和生产。我们的客户包括位于美国和国外的大多数*的制药和生物技术公司。

USbiological公司致力于以价值，诚信和真正的个人购买体验降低研究成本。USbiological的生物化学，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。产品可以从负担得起的研究数量到大批量用于工艺开发和生产。

USBio（UnitedStatesBiological，或简称USBiological）位于麻省斯万普斯科特(Swampscott,MA)。作为全美最大的抗原抗体和生化试剂供应商，USBiological目前向全球六十余个国家的科研工作者提供约150,000种抗体、抗原和生化试剂，以质量卓越闻名。主要产品种类包括：抗体、生化试剂、基因克隆相关产品、培养基、生长因子等细胞因子、分子生物学试剂。美国USBiological的产品服务于免疫学，分子生物学，分子遗传学，体外诊断，组织培养等科研领域。USBiological一直恪守“为您的研究减少成本”原则，提供高纯度、高品质的产品，并在大多数生化试剂、生物与培养基产品线上保持最高的性价比。USBiological的产品被广泛用于各种科学研究领域，包括基因组研究、生物技术、药物研发和疾病诊断等。USBiological的产品从小型科研级到生物制品大规模级规格均有提供。众多全球顶ji的生物制药和生物技术公司都在使用USBiological的高品质产品。

usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。

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