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IBL/ACTH ELISA/RE53081/

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RE53081

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4000-520-616

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Kitsize12x8MethodELISAIncubationtime1x2h,1x20minStandardrange11-416pg/mLSpecimen/Volumes200µLEDTA-PlasmaSubstrate/isotopeTMB450nmRegulatoryStatus:EU:CEDetailsfor: ACTHELISAThefastestELISAavailableIBLpresentsanew,simplifiedadrenocorticotropichormone(ACTH)ELISA,withthefollowingadvantages:Assaytimeof2hours(comparedto4hoursbefore)Easiercalculationofresults(singleplatereADIngat450nm)Highanalyticalsensitivity(LLOD:< 1 pg/mL)Widedynamicrange(0-416pg/mL)ThisnewACTHassaycorrelateswellwithotherELISAsavailableonthemarket.Thisenablesaneasytransitionandsavesthelaboratorytime,effortandmoney.PleasenotethecataloguenumberRE53081ofthenewACTHELISAforordering.MeasuringplasmaACTH(synonyms:corticotropin,cosyntropin)levelsisextremelyusefulinthediagnosisofbothCushing"ssyndromeandadrenalinsufficiency.ACTHlevelsinthebloodaremeasuredtohelpdetect,diagnoseandmonitorconditionsassociatedwithexcessiveordeficientcortisollevelsinthebody.AsthelevelofACTHnormallychangesintheoppositedirectiontothelevelofcortisol,weadditionallyrecommendourcortisolassays(forserum,urineand/orsalivameasurement)forthepurposeofdifferentiatingamongthedifferentpituitaryoradrenalconditions.GeneralinformationontheACTHELISAThetestisusefulfordetectingelevatedanddeficientACTHlevels.IndicationsforusePatientswiththefollowingconditionsmayhavehigherthannormallevelsofACTH:Addison’sdiseaseorprimaryadrenalinsufficiencyCongenitaladrenalhyperplasiaCushing’ssyndromeCushing’sdiseaseMultipleendocrineneoplasia(MEN),typeIPatientswiththefollowingconditionsmayhavelowerthannormallevelsofACTH:Hypopituitarismand/orsecondaryadrenalinsufficiencyAdrenaltumorOthercortisol-producingtumorsACTHisa39-amino-acidpolypeptidewithamolecularweightof4540Da.ACTHissecretedbycorticotrophsintheanteriorlobeofthepituitarygland(oradenohypophysis)inresponsetocorticotropin-releasinghormone(CRH)releasedbythehypothalamus.ACTHissynthesizedfrompre-proopiomelanocortin(pre-POMC).Theremovalofthesignalpeptideduringtranslationproducesthe241-amino-acidpolypeptidePOMC,whichundergoesaseriesofpost-translationalmodificationssuchasphosphorylationandglycosylationbeforeitisproteolyticallycleavedbyendopeptidasestoyieldvariouspolypeptidefragmentswithvaryingphysiologicalactivity.ACTHisanimportantcomponentofthehypothalamic-pituitary-adrenalaxisandisoftenproducedinresponsetoBIOLOGicalstress.Itstimulatesthesecretionofglucocorticoidsteroidhormonesfromtheadrenalcortexcells,especiallyinthezonafasciculataoftheadrenal.ACTHactsbybindingtocellsurfaceACTHreceptors,whicharelocatedprimarilyonadrenocorticalcellsoftheadrenalcortex.Synonyms:Adrenocorticotropichormone,Corticotropin,CosyntropinThisproductrepresentstherightalternativetodiscontinuedACTHRIA.Pleasecontactusifyoushouldneedanykitfortrialpurposes!Orifyoushouldneedanysupportregardingcomparisonstudies.Wewillbehappytoprovideyouwithexpectedhelp.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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