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IBL/Annexin-V IgG/IgM ELISA/RE70451/

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RE70451

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Kitsize12x8MethodELISAIncubationtime1x30min,2x15minStandardrange1-300IU/ml;cut-off:15IU/mlSpecimen/Volumes10µLserumSubstrate/isotopeTMB450nmRegulatoryStatus:ForresearchuseonlyDetailsfor: Annexin-VIgG/IgMELISAAnnexinIgG/IgMELISAisasolidphaseenzymeimmunoassayforthequantitativeandqualitativedetectionofIgGand/orIgMantibodiesagainstAnnexinVinhumanserum.TheassayemploysnativehumanAnnexinV.Theassayisatoolinthediagnosisoftheantiphospholipidsyndrome.AntibodiestargetingAnnexinVbelongtothefamilyofantiphospholipidantibodiesincludingforexampleanti-Cardiolipin,ß2-glycoproteinI(ß2-GPI)andProthrombinantibodiesandareassociatedwithprimaryandsecondaryantiphospholipidsyndrome(APS).Clinically,theAPSischaracterizedbyvenousandarterialthrombosisandseverepregnancycomplications.Anti-AnnexinVantibodieshavebeendetectedinpatientswithsystemicautoimmunediseases,especiallysystemiclupuserythematosus,buthavealsobeenassociatedtointrauterinefetalloss,recurrentabortionsandpreeclampsiainAPSpatients.AnnexinVisaCa2+-dependent,phospholipid-bindingproteinwithpotentanticoagulantactivitythatisabundantincellsexposedtoblood,suchasplatelets,trophoblasts,andendothelialcells.ThehighconcentrationofannexinVinplacentalsyncytiotrophoblastshasbeenproposedasamechanismtomaintainbloodfluidityonthesurfaceoftheplacentaandplacentalintergrity.ItthereforeunsuressupplyofthefoetuswithnutrientsandfetalviABIlity.ThrombosisandpregnancylossintheantiphospholipidsyndromemaybecausedbydisruptionofthisAnnexinVshieldbyantiphospholipidantibodiesleADIngtoanincreaseinthequantityofthrombogenicphospholipidsexposedtothecirculatingblood.Anti-AnnexinVautoantibodiesaresupposedtointerferewiththeanticoagulantfunctionofAnnexinVcausingplacentalthrombosisanddisruption.Consequently,thedetectionofanti-AnnexinantibodiesshouldbeincludedintheSEROlogicaldiagnosisofAPSespeciallyinfemalepatientsatriskforobstetriccomplications.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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