首页 > IBL > IBL/Cortisol Saliva Luminescence Immunoassay/RE62119/

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IBL/Cortisol Saliva Luminescence Immunoassay/RE62119/

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RE62119

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Kitsize10x12x8MethodLuminescenceImmunoassayIncubationtime1x3h;1x10minStandardrange0.015-3.20µg/dLSpecimen/Volumes20µLSalivaSubstrate/isotopeLuminolRegulatoryStatus:EU:CE,CDN:IVDDetailsfor: CortisolSalivaLuminescenceImmunoassayTheIBLInternationalCortisolSalivaLuminescenceImmunoassayisintendedforthein-vitro-diagnosticquantitativedeterminationofCortisolinhumansalivaandforuseasanaidinthediagnosisandtreatmentofadrenaldisorders.Thisdeviceisnotintendedforpoint-of-caresettings.Cortisol(alsoknownashydrocortisone,compoundF)isthemainglucocorticoidinhumansandisproducedinthezonafasciculataoftheadrenalcortex.90%ofthecirculatingcortisolareboundtocorticoidbindingglobulin(CBG,Transcortin),ca.7%areboundtoalbuminandonly1–3%areunbound.Onlythelatterpartrepresentstheactiveformofcortisol.Thefreecortisolisreleasedinsalivaandisexcretedviathekidneysasasmallpartamongthemetabolitesofcortisol.TheleveloffreecortisolinbloodregulatesmainlyitssecretionintheadrenalcortexinanegativefeedbackmechanismviaCRH(corticotropinreleasinghormone)inthehypothalamicregionandtheACTHinthepituitarygland,butitisalsoaffectedbydifferentsituationsaboveallbystress.Inhumansthereisaphysiologicalfluctuationofcortisolachievingthehighestlevelinthemorningandthelowestduringmidnight.Thisfluctuationofcortisolplasmalevelisreflectedinsalivanormallywithapeakinthefirst90minutesafterwakeup.Thecortisolmeasurementisindicatedinadrenaldisorders.Duetothediurnalfluctuationsofcortisolasalivarysamplecollectionisaneasymethodwithoutthestressofrepeatedvenipunctures.OurNewIBLCortisolSalivaLuminescenceImmunoassayiscalibratedtothereferencemethodoftheLC-MS/MSandreplacestheoldversionreferencedRE62019.TheLuminescenceIAisalsoavailableinregularformat(12x8tests),withthecataloguenumberRE62111.DistributedbyIBLInternationalForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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