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IBL/Reverse T3 (rT3) ELISA/30123153/

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Kitsize12x8MethodELISAIncubationtime1x1h(37°C),1x30min(37°C),1x15min(37°C)Standardrange0.02–2ng/mLSpecimen/Volumes25µLSerum,EDTAPlasmaSubstrate/isotopeTMB,450nmRegulatoryStatus:EU:CEDetailsfor: ReverseT3(rT3)ELISAForthedirectquantitativedeterminationofReverseTriiodothyronine(rT3)inhumanserumandplasmabyanenzymeimmunoassay.3,3’,5’-Triiodo-L-thyroninealsoknownasreversetriiodothyronineorreverseT3(rT3),differsfrom3,3’,5’-Triiodo-L-thyronine(T3)inthepositionsoftheiodineatomsinthemolecule.ThemajorityofcirculatoryrT3issynthesizedbyperipheraldeiodinationofthyroxine(T4).BothT3andrT3bindtothyroidhormonereceptors,butincontrasttoT3,rT3hasnotbeenfoundyettostimulatereceptormetabolicactivity;itblocksreceptorsitesfromT3activation.TheratioofrT3toT3isavaluablebioMarkerofthemetabolismandfunctionofthyroidhormonesbecausetheprocessof5’monodeiodinationthatconvertsT4toT3andrT3to3,3’-T2isinhibitedinanumberofnon-thyroidalconditionssuchasfasting,anorexianervosa,malnutrition,diabetesmellitus,stress,severetraumaorinfection,hemorrhagicshock,hepaticdysfunction,pulmonarydiseasesandothers.Thisscenarioisknownas"Sickeuthyroid"syndromeor“LowT3”syndrome.AnelevatedratioofrT3overT3isthereforeindicativeof"sickeuthyroid"syndromeandhelpstoexcludeadiagnosisofhypothyroidism,particularlyincriticallyillpatients1-9.TheconcentrationofrT3couldbehighinpatientsonthefollowingmedications:amiodarone,dexamethasone,propylthiouracil,ipodate,propranolol,andtheanesthetichalothane.TheconcentrationofrT3couldbelowinpatientsonDilantin,whichdecreasesrT3duetoitsdisplacementfromthyroxine-bindingglobulinandthereforegeneratesanexcessiveclearanceofrT3.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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