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IBL/17-OH-Progesterone ELISA/RE52071/

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RE52071

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4000-520-616

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Kitsize12x8MethodELISAIncubationtime1x60min,1x30minStandardrange0.15-20ng/mLSpecimen/Volumes25µLserum,plasmaSubstrate/isotopeTMB450nmRegulatoryStatus:EU:CE,CDN:IVDDetailsfor: 17-OH-ProgesteroneELISA17-OH-progesterone(17-OHP)isthemostsuitablebiochemicalMarkerforthediagnosisofcongenitaladrenalhyperplasia(CAH).CAHhasaprevalenceof1-20in10,000childrenanditisoneofthemostfrequentinbornendocrinedisorders.ThemostcommonformofCAHisduetoadeficiencyoftheenzyme21-hydroxylase.Dependingontheseverityoftheenzymaticdefect,theCAHrelatedsymptomsvaryfromsaltlostsyndromeininfantstohirsutismand/orinfertilitythatmanifestduringpubertyoradulthood(late-onsetCAH).AdvantagesoftheIBLInternational17-OHPELISAExcellentanalyticalcharacteristicsForthe17-OHPserumELISAage-dependentreferencerangesforchildrenEasy17-OHPmonitoringinsalivaSerum,plasmaELISA:EU:CEEasytoadapttoautomatedinstrumentsMeasuring17-OHPenablesearlydiagnosisandtreatmentofpatientssufferingfromCAH.Femalepatientswithlate-onsetCAHusuallyhave17-OHPconcentrationsabovethereferenceintervalduringthefollicularphaseofthemenstrualcycle.17-OHPissecretedinabundantexcessinaffectedinfantswith21-hydroxylasedeficiencywhencomparedtohealthychildren.Normalserum17-OHPvaluesininfantsandchildrenareshownbelow.Normal17-OHPserumvaluesforinfantsandchildren17-OH-Progesteronein195seraofinfants17-OH-Progesteronein139seraofchildrenThisproductrepresentstherightalternativetothesoondiscontinued17-aOH-ProgesteroneCACRIAfromSiemens.Pleasecontactusifyoushouldneedanykitfortrialpurposes!Orifyoushouldneedanysupportregardingcomparisonstudies.Wewillbehappytoprovideyouwithexpectedhelp.ExcellentreplacementforRIAAvalidationstudybytheAustralianlaboratoryACTshowsthatIBL’s17-OH-ProgesteroneELISAprovidesanexcellentalternativefortheSiemensHealthcareDiagnostics(formerlyDPC)17-aOH-ProgesteroneRIA.Thedatacanviewedhere:EscapefromRIA-ACTPoster2013Pleasecontactusifyouwouldbeinterestedtoperformyourowninternalvalidationstudy. HighcorrelationtoGC-MS/MSshowninExternalQualityAssessmentSchemeThelatestsurveystudybytheReferenceforBioanalyticsinBonn,Germany,againconfirmedthecorrectcalibrationandreliABIlityofourassay.RfBsurveyresultsExcerptfromtheInstructionsforUseEnzymeimmunoassayforthein-vitro-diagnosticquantitativedeterminationof17-OH-Progesteroneinhumanserumandplasma.17-OH-progesterone(17-OHP)isthemostsuitablebiochemicalmarkerforthediagnosisofCongenitalAdrenalHyperplasia(CAH).CAHhasaprevalenceofaround1-20in10,000childrenandisoneofthemostfrequentinbornendocrinedisorders.Thespectrumofclinicalpresentationsrangesfromformswithneonatalsymptoms,i.e.saltwastingandsimplevirilizingforms,tonon-classicalformsthatmightnotmanifestuntiladulthood.MeasuringthissteroidenablesearlydiagnosisandtreatmentinpatientssufferingfromCAH.17-OHPissecretedinabundantexcessinaffectedinfantsdueto21-hydroxylasedeficiency.Femalepatientswithlate-onsetCAHusuallyhave17-OHPconcentrationsabovethereferenceintervalforthefollicularphaseofthemenstrualcycle.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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