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IBL/25-OH Vitamine D3 Radioimmunoassay/MG11021/

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MG11021

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Kitsize96MethodRIA(CT)Incubationtime1x2hStandardrange3.5-145.2ng/mLSpecimen/Volumes200µLserum,plasmaSubstrate/isotope125I<280kBqRegulatoryStatus:EU:CEDetailsfor: 25-OHVitamineD3Radioimmunoassay25-HydroxyvitaminD3(25-OHD3)isaseco-steroidproducedintheliverby25-hydroxylationofcholecalciferolorVitaminD3.25OHD3isaprecursorforotherVitaminD3metabolitesandhasonlyalimitedBIOLOGicalactivityinitself.Asmallproportionofthe25-OHD3isfurtherhydroxylatedinthekidney,underdirectregulationbyparathyroidhormoneandionisedcalciumlevels,toformthebiologically-activecalcitropichormone1,25-dihydroxyvitaminD3.FurtherhydroxylationandmetabolismofvitaminDproducescompoundsthatarewatersolubleandreadilyexcreted.Radioimmunoassayfortheinvitroquantitativemeasurementof25OH-Vit.D3inhumanserumandheparinplasma.A.Physiologicalfunctionof25OH-Vit.D325-HydroxyvitaminD3(25OHD3)isthetrivialnameof9,10-secocholesta-5,7,10(19)-triene-3β,25-diol.Thissecosteroidisproducedintheliverby25-hydroxylationofcholecalciferolorVitaminD3.25OHD3isaprecursorforotherVitaminDmetabolitesandhasonlyalimitedbiologicalactivityinitself.Themostactivederivativeis1α,25-HydroxyvitaminD3,producedinthekidney(orplacenta)by1α-hydroxylationof25OHD3.Thishormonallyregulatedsteroidstimulatestheintestinalabsorptionofbothcalciumandphosphorus.Italsostimulatesboneresorptionandmineralisationtherebypreventingthedevelopmentofrickets,osteoporosisorosteomalacia.ThisVitaminDhormonemightalsobeactiveinothertissuesresponsIBLeforcalciumtransport(placenta,kidney,mammarygland,...)andendocrineglands(beta-cells,parathyroidglands,...).25-hydroxyvitaminD3isamainprecursorforthemetabolites.B.RegulatorymechanismTheproductionof25-hydroxyvitaminDmainlyoccursintheliveralthoughothertissues(intestine,kidney)mightperformthesamehydroxylation.Althoughtheremightbesomefeedbackinhibitionof25-hydroxyvitaminDonitsownproduction,ahighersubstrateavailABIlity(VitaminD3)resultsinhigher25-hydroxyvitaminDproductionandhighercirculating25-hydroxyvitaminDconcentrationsinblood.C.ClinicalapplicationsThisassayisofimportanceforthediagnosisofVitaminDdeficiency,insufficiencyorintoxication.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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